Cargando…

The Unconventional Role of Acid Sphingomyelinase in Regulation of Retinal Microangiopathy in Diabetic Human and Animal Models

OBJECTIVE: Acid sphingomyelinase (ASM) is an important early responder in inflammatory cytokine signaling. The role of ASM in retinal vascular inflammation and vessel loss associated with diabetic retinopathy is not known and represents the goal of this study. RESEARCH DESIGN AND METHODS: Protein an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Opreanu, Madalina, Tikhonenko, Maria, Bozack, Svetlana, Lydic, Todd A., Reid, Gavin E., McSorley, Kelly M., Sochacki, Andrew, Perez, Gloria I., Esselman, Walter J., Kern, Timothy, Kolesnick, Richard, Grant, Maria B., Busik, Julia V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161322/ https://www.ncbi.nlm.nih.gov/pubmed/21771974 http://dx.doi.org/10.2337/db10-0550

Ejemplares similares

N-3 Polyunsaturated Fatty Acids Prevent Diabetic Retinopathy by Inhibition of Retinal Vascular Damage and Enhanced Endothelial Progenitor Cell Reparative Function
por: Tikhonenko, Maria, et al.
Publicado: (2013)

Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elovl2 and Elovl4
por: Tikhonenko, Maria, et al.
Publicado: (2010)

Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators
por: Busik, Julia V., et al.
Publicado: (2008)

Changes in the Daily Rhythm of Lipid Metabolism in the Diabetic Retina
por: Wang, Qi, et al.
Publicado: (2014)

Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway
por: Huang, Chao, et al.
Publicado: (2018)

Carbon Monoxide and Nitric Oxide Mediate Cytoskeletal Reorganization in Microvascular Cells via Vasodilator-Stimulated Phosphoprotein Phosphorylation: Evidence for Blunted Responsiveness in Diabetes
por: Li Calzi, Sergio, et al.
Publicado: (2008)

Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables
por: van Duinkerken, Eelco, et al.
Publicado: (2012)

Per2 Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow
por: Bhatwadekar, Ashay D., et al.
Publicado: (2013)

Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock
por: Busik, Julia V., et al.
Publicado: (2009)

Diminished Alveolar Microvascular Reserves in Type 2 Diabetes Reflect Systemic Microangiopathy
por: Chance, William W., et al.
Publicado: (2008)

Combination Therapies Prevent the Neuropathic, Proinflammatory Characteristics of Bone Marrow in Streptozotocin-Induced Diabetic Rats
por: Dominguez, James M., et al.
Publicado: (2015)

miR-92a Corrects CD34(+) Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation
por: Bhatwadekar, Ashay D., et al.
Publicado: (2015)

Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats
por: Berti-Mattera, Liliana N., et al.
Publicado: (2008)

Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes
por: Rosca, Mariana G., et al.
Publicado: (2012)

Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice
por: Li, Guangyuan, et al.
Publicado: (2012)

CD40 in Retinal Müller Cells Induces P2X(7)-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy
por: Portillo, Jose-Andres C., et al.
Publicado: (2017)

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission
por: Wang, Qilong, et al.
Publicado: (2017)

Transient Inhibition of Transforming Growth Factor-β1 in Human Diabetic CD34(+) Cells Enhances Vascular Reparative Functions
por: Bhatwadekar, Ashay D., et al.
Publicado: (2010)

Liver X Receptor Modulates Diabetic Retinopathy Outcome in a Mouse Model of Streptozotocin-Induced Diabetes
por: Hazra, Sugata, et al.
Publicado: (2012)

Partial Inhibition of Insulin Secretion Results in Glucose Intolerance but Not Hyperglucagonemia
por: Ramanathan, Ranjani P., et al.
Publicado: (2011)

Corneal Confocal Microscopy Detects Early Nerve Regeneration in Diabetic Neuropathy After Simultaneous Pancreas and Kidney Transplantation
por: Tavakoli, Mitra, et al.
Publicado: (2013)

Patrolling Monocytes Are Recruited and Activated by Diabetes to Protect Retinal Microvessels
por: Tecilazich, Francesco, et al.
Publicado: (2020)

Aortic intima media thickness in children and adolescents with type 1 diabetes: A systematic review
por: Gow, Megan L., et al.
Publicado: (2022)

Levels of Oxidized LDL and Advanced Glycation End Products–Modified LDL in Circulating Immune Complexes Are Strongly Associated With Increased Levels of Carotid Intima-Media Thickness and Its Progression in Type 1 Diabetes
por: Lopes-Virella, Maria F., et al.
Publicado: (2011)

Cumulative Risk, Age at Onset, and Sex-Specific Differences for Developing End-Stage Renal Disease in Young Patients With Type 1 Diabetes: A Nationwide Population-Based Cohort Study
por: Möllsten, Anna, et al.
Publicado: (2010)

Childhood type 1 diabetes is associated with abnormal bone development
por: Vora, Komal Ashokbhai, et al.
Publicado: (2022)

Baroreflex Sensitivity Impairment During Hypoglycemia: Implications for Cardiovascular Control
por: Rao, Ajay D., et al.
Publicado: (2016)

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities
por: Carvalho, Cristina, et al.
Publicado: (2012)

Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy
por: Barutta, Federica, et al.
Publicado: (2011)

Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis
por: Rajwani, Adil, et al.
Publicado: (2012)

Higher frequency of cardiovascular autonomic neuropathy in youth with type 2 compared to type 1 diabetes: Role of cardiometabolic risk factors
por: Varley, Benjamin J., et al.
Publicado: (2022)

GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop
por: Giacco, Ferdinando, et al.
Publicado: (2015)

Mineralocorticoid Receptor Blockade Improves Coronary Microvascular Function in Individuals With Type 2 Diabetes
por: Garg, Rajesh, et al.
Publicado: (2015)

Decreased IRS2 and TIMP3 Expression in Monocytes From Offspring of Type 2 Diabetic Patients Is Correlated With Insulin Resistance and Increased Intima-Media Thickness
por: Cardellini, Marina, et al.
Publicado: (2011)

PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment
por: Liu, Longhua, et al.
Publicado: (2020)

Enhanced Expression of Janus Kinase–Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy
por: Berthier, Celine C., et al.
Publicado: (2009)

Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy
por: Marshall, Andrew G., et al.
Publicado: (2017)

Differences in retinopathy prevalence and associated risk factors across 11 countries in three continents: A cross‐sectional study of 156,090 children and adolescents with type 1 diabetes
por: Bratina, Natasa, et al.
Publicado: (2022)

Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children With Type 1 Diabetes: Association With Hyperglycemia
por: Mauras, Nelly, et al.
Publicado: (2015)

Neuronatin: A New Inflammation Gene Expressed on the Aortic Endothelium of Diabetic Mice
por: Mzhavia, Nino, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_2oe1aomlihoju6vsism31klfgf