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Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet β-Cells

OBJECTIVE: Ghrelin reportedly restricts insulin release in islet β-cells via the Gα(i2) subtype of G-proteins and thereby regulates glucose homeostasis. This study explored whether ghrelin regulates cAMP signaling and whether this regulation induces insulinostatic cascade in islet β-cells. RESEARCH...

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Detalles Bibliográficos
Autores principales:	Dezaki, Katsuya, Damdindorj, Boldbaatar, Sone, Hideyuki, Dyachok, Oleg, Tengholm, Anders, Gylfe, Erik, Kurashina, Tomoyuki, Yoshida, Masashi, Kakei, Masafumi, Yada, Toshihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161328/ https://www.ncbi.nlm.nih.gov/pubmed/21788571 http://dx.doi.org/10.2337/db11-0368

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