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Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-δ

OBJECTIVE: Glucagon-like peptide 1 (GLP-1) is a gut-brain hormone that regulates food intake, energy metabolism, and cardiovascular functions. In the brain, through a currently unknown molecular mechanism, it simultaneously reduces femoral artery blood flow and muscle glucose uptake. By analogy to p...

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Detalles Bibliográficos
Autores principales: Cabou, Cendrine, Vachoux, Christelle, Campistron, Gérard, Drucker, Daniel J., Burcelin, Rémy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161335/
https://www.ncbi.nlm.nih.gov/pubmed/21810595
http://dx.doi.org/10.2337/db11-0464