Cargando…

Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-δ

OBJECTIVE: Glucagon-like peptide 1 (GLP-1) is a gut-brain hormone that regulates food intake, energy metabolism, and cardiovascular functions. In the brain, through a currently unknown molecular mechanism, it simultaneously reduces femoral artery blood flow and muscle glucose uptake. By analogy to p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cabou, Cendrine, Vachoux, Christelle, Campistron, Gérard, Drucker, Daniel J., Burcelin, Rémy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161335/ https://www.ncbi.nlm.nih.gov/pubmed/21810595 http://dx.doi.org/10.2337/db11-0464

Ejemplares similares

Brain Glucagon-Like Peptide-1 Regulates Arterial Blood Flow, Heart Rate, and Insulin Sensitivity
por: Cabou, Cendrine, et al.
Publicado: (2008)

Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism
por: Li, Mengyao, et al.
Publicado: (2015)

Resveratrol Increases Glucose Induced GLP-1 Secretion in Mice: A Mechanism which Contributes to the Glycemic Control
por: Dao, Thi-Mai Anh, et al.
Publicado: (2011)

Duodenal PKC-δ and Cholecystokinin Signaling Axis Regulates Glucose Production
por: Breen, Danna M., et al.
Publicado: (2011)

GLP-1 and GLP-2 as Yin and Yang of Intestinal Lipoprotein Production: Evidence for Predominance of GLP-2–Stimulated Postprandial Lipemia in Normal and Insulin-Resistant States
por: Hein, Gustavo J., et al.
Publicado: (2013)

Essential Role Of High Glucose-Induced Overexpression Of PKCβ And PKCδ In GLP-1 Resistance In Rodent Cardiomyocytes
por: Pan, Xietian, et al.
Publicado: (2019)

Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats
por: Knight, Colette M., et al.
Publicado: (2011)

GLP-1 Effects on Islets: Hormonal, Neuronal, or Paracrine?
por: Donath, Marc Y., et al.
Publicado: (2013)

Glucolipotoxicity and GLP-1 secretion
por: Hong, Jung-Hee, et al.
Publicado: (2021)

Regulation of Hypothalamic Neuronal Sensing and Food Intake by Ketone Bodies and Fatty Acids
por: Le Foll, Christelle, et al.
Publicado: (2014)

Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing
por: Knauf, Claude, et al.
Publicado: (2008)

The Interplay of Endothelial P2Y Receptors in Cardiovascular Health: From Vascular Physiology to Pathology
por: Cabou, Cendrine, et al.
Publicado: (2022)

MON-666 Glucokinase Within the Hypothalamic Paraventricular Nucleus Is Important in GLP-1 Release
por: Ratnasabapathy, Risheka
Publicado: (2020)

The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice
por: Burmeister, Melissa A., et al.
Publicado: (2017)

Diabetes-Associated Common Genetic Variation and Its Association With GLP-1 Concentrations and Response to Exogenous GLP-1
por: Smushkin, Galina, et al.
Publicado: (2012)

Exploring the GLP-1–GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography
por: Manell, Elin, et al.
Publicado: (2021)

PKCα and PKCδ: Friends and Rivals
por: Black, Jennifer D., et al.
Publicado: (2022)

Telmisartan Improves Insulin Resistance of Skeletal Muscle Through Peroxisome Proliferator–Activated Receptor-δ Activation
por: Li, Li, et al.
Publicado: (2013)

Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice
por: Attané, Camille, et al.
Publicado: (2012)

Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry
por: Yang, Mengliu, et al.
Publicado: (2017)

Hypothalamic Protein Kinase C Regulates Glucose Production
por: Ross, Rachel, et al.
Publicado: (2008)

Hypothalamic Leucine Metabolism Regulates Liver Glucose Production
por: Su, Ya, et al.
Publicado: (2012)

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin
por: Rahmouni, Kamal, et al.
Publicado: (2009)

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production
por: Yang, Clair S., et al.
Publicado: (2010)

Identification of Hypothalamic Glucoregulatory Neurons That Sense and Respond to Changes in Glycemia
por: Deem, Jennifer D., et al.
Publicado: (2023)

Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets
por: Pears, Catherine J., et al.
Publicado: (2008)

GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats
por: Habegger, Kirk M., et al.
Publicado: (2014)

PKCδ Blues for the β-Cell
por: Schmitz-Peiffer, Carsten, et al.
Publicado: (2010)

Anorexia and Impaired Glucose Metabolism in Mice With Hypothalamic Ablation of Glut4 Neurons
por: Ren, Hongxia, et al.
Publicado: (2015)

Variability of Directly Measured First-Pass Hepatic Insulin Extraction and Its Association With Insulin Sensitivity and Plasma Insulin
por: Asare-Bediako, Isaac, et al.
Publicado: (2018)

PSUN299 GLP-1 Contribution to Insulin Secretory Response to Protein Ingestion and Insulin Kinetics Following Gastric Bypass and Sleeve Gastrectomy
por: Rayas, Maria, et al.
Publicado: (2022)

Overexpressed PKCδ Downregulates the Expression of PKCα in B16F10 Melanoma: Induction of Apoptosis by PKCδ via Ceramide Generation
por: Halder, Kuntal, et al.
Publicado: (2014)

Insulin enhances renal glucose excretion: relation to insulin sensitivity and sodium-glucose cotransport
por: Ferrannini, Ele, et al.
Publicado: (2020)

Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight
por: Kim, Hyun-Kyong, et al.
Publicado: (2010)

Distinct Neuronal Projections From the Hypothalamic Ventromedial Nucleus Mediate Glycemic and Behavioral Effects
por: Faber, Chelsea L., et al.
Publicado: (2018)

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons
por: Varela, Luis, et al.
Publicado: (2017)

Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity
por: Kim, Jung Dae, et al.
Publicado: (2017)

CCK Stimulation of GLP-1 Neurons Involves α(1)-Adrenoceptor–Mediated Increase in Glutamatergic Synaptic Inputs
por: Hisadome, Kazunari, et al.
Publicado: (2011)

Physical Activity and Insulin Sensitivity: The RISC Study
por: Balkau, Beverley, et al.
Publicado: (2008)

Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity
por: Ramalingam, Latha, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_joejmkugfm4bu4fh53md38ht0c