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A Comparison of Merkel Cell Carcinoma and Melanoma: Results from the California Cancer Registry

INTRODUCTION: Melanoma and Merkel cell carcinoma (MCC) are both aggressive skin malignancies associated with immunosuppression and possible UV exposure. Both tumors get similar surgical treatment; however, MCC is a relatively rare tumor in which less is known about prognosis and clinical behavior. M...

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Autores principales: Grabowski, Julia, Saltzstein, Sidney L, Sadler, Georgia Robins, Tahir, Zunera, Blair, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161663/
https://www.ncbi.nlm.nih.gov/pubmed/21892294
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author Grabowski, Julia
Saltzstein, Sidney L
Sadler, Georgia Robins
Tahir, Zunera
Blair, Sarah
author_facet Grabowski, Julia
Saltzstein, Sidney L
Sadler, Georgia Robins
Tahir, Zunera
Blair, Sarah
author_sort Grabowski, Julia
collection PubMed
description INTRODUCTION: Melanoma and Merkel cell carcinoma (MCC) are both aggressive skin malignancies associated with immunosuppression and possible UV exposure. Both tumors get similar surgical treatment; however, MCC is a relatively rare tumor in which less is known about prognosis and clinical behavior. METHODS: The California Cancer Registry (CCR), a population-based registry, was reviewed from the years 1988–2003. Merkel cell carcinoma and melanoma were compared with relation to gender, age, ethnicity, disease stage, site, and survival. RESULTS: A total of 113,187 cases of melanoma and 1,878 cases of MCC were identified in the CCR. Though both cancers are more common in men than in women, MCC had a higher incidence in men than melanoma (63% vs 57% p < 0.005). MCC occurs in the more elderly, with 73.6% of cases occurring in people over 70 years. In contrast, 69% of melanoma cases occurred in people younger than 70 years (p < 0.005). MCC shows a predilection for the head and neck compared to melanoma (47% vs 25.8%) Additionally, melanoma occurs more frequently on the trunk than MCC (30% vs 8.7%). Finally, the 10-year cumulative survival is lower for MCC than for melanoma (17.7% vs 61.3%, p < 0.005). CONCLUSION: Many clinicians assume MCC and melanoma behave similarly. However, MCC occurs in an older population, more frequently on the head and neck, in a higher percentage of men. Additionally, MCC has a higher rate of regional metastasis and thus may have more of a benefit from regional staging procedures. Overall, MCC has a worse prognosis.
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spelling pubmed-31616632011-09-02 A Comparison of Merkel Cell Carcinoma and Melanoma: Results from the California Cancer Registry Grabowski, Julia Saltzstein, Sidney L Sadler, Georgia Robins Tahir, Zunera Blair, Sarah Clin Med Oncol Original Research INTRODUCTION: Melanoma and Merkel cell carcinoma (MCC) are both aggressive skin malignancies associated with immunosuppression and possible UV exposure. Both tumors get similar surgical treatment; however, MCC is a relatively rare tumor in which less is known about prognosis and clinical behavior. METHODS: The California Cancer Registry (CCR), a population-based registry, was reviewed from the years 1988–2003. Merkel cell carcinoma and melanoma were compared with relation to gender, age, ethnicity, disease stage, site, and survival. RESULTS: A total of 113,187 cases of melanoma and 1,878 cases of MCC were identified in the CCR. Though both cancers are more common in men than in women, MCC had a higher incidence in men than melanoma (63% vs 57% p < 0.005). MCC occurs in the more elderly, with 73.6% of cases occurring in people over 70 years. In contrast, 69% of melanoma cases occurred in people younger than 70 years (p < 0.005). MCC shows a predilection for the head and neck compared to melanoma (47% vs 25.8%) Additionally, melanoma occurs more frequently on the trunk than MCC (30% vs 8.7%). Finally, the 10-year cumulative survival is lower for MCC than for melanoma (17.7% vs 61.3%, p < 0.005). CONCLUSION: Many clinicians assume MCC and melanoma behave similarly. However, MCC occurs in an older population, more frequently on the head and neck, in a higher percentage of men. Additionally, MCC has a higher rate of regional metastasis and thus may have more of a benefit from regional staging procedures. Overall, MCC has a worse prognosis. Libertas Academica 2008-04-01 /pmc/articles/PMC3161663/ /pubmed/21892294 Text en © 2008 the author(s), publisher and licensee Libertas Academica Ltd. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license http://creativecommons.org/licenses/by/3.0/).
spellingShingle Original Research
Grabowski, Julia
Saltzstein, Sidney L
Sadler, Georgia Robins
Tahir, Zunera
Blair, Sarah
A Comparison of Merkel Cell Carcinoma and Melanoma: Results from the California Cancer Registry
title A Comparison of Merkel Cell Carcinoma and Melanoma: Results from the California Cancer Registry
title_full A Comparison of Merkel Cell Carcinoma and Melanoma: Results from the California Cancer Registry
title_fullStr A Comparison of Merkel Cell Carcinoma and Melanoma: Results from the California Cancer Registry
title_full_unstemmed A Comparison of Merkel Cell Carcinoma and Melanoma: Results from the California Cancer Registry
title_short A Comparison of Merkel Cell Carcinoma and Melanoma: Results from the California Cancer Registry
title_sort comparison of merkel cell carcinoma and melanoma: results from the california cancer registry
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161663/
https://www.ncbi.nlm.nih.gov/pubmed/21892294
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