Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii

Although the number of reconstructed metabolic networks is steadily growing, experimental data integration into these networks is still challenging. Based on elementary flux mode analysis, we combine sequence information with metabolic pathway analysis and include, as a novel aspect, circadian regul...

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Autores principales: Schäuble, Sascha, Heiland, Ines, Voytsekh, Olga, Mittag, Maria, Schuster, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161734/
https://www.ncbi.nlm.nih.gov/pubmed/21887226
http://dx.doi.org/10.1371/journal.pone.0023026
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author Schäuble, Sascha
Heiland, Ines
Voytsekh, Olga
Mittag, Maria
Schuster, Stefan
author_facet Schäuble, Sascha
Heiland, Ines
Voytsekh, Olga
Mittag, Maria
Schuster, Stefan
author_sort Schäuble, Sascha
collection PubMed
description Although the number of reconstructed metabolic networks is steadily growing, experimental data integration into these networks is still challenging. Based on elementary flux mode analysis, we combine sequence information with metabolic pathway analysis and include, as a novel aspect, circadian regulation. While minimizing the need of assumptions, we are able to predict changes in the metabolic state and can hypothesise on the physiological role of circadian control in nitrogen metabolism of the green alga Chlamydomonas reinhardtii.
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spelling pubmed-31617342011-09-01 Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii Schäuble, Sascha Heiland, Ines Voytsekh, Olga Mittag, Maria Schuster, Stefan PLoS One Research Article Although the number of reconstructed metabolic networks is steadily growing, experimental data integration into these networks is still challenging. Based on elementary flux mode analysis, we combine sequence information with metabolic pathway analysis and include, as a novel aspect, circadian regulation. While minimizing the need of assumptions, we are able to predict changes in the metabolic state and can hypothesise on the physiological role of circadian control in nitrogen metabolism of the green alga Chlamydomonas reinhardtii. Public Library of Science 2011-08-22 /pmc/articles/PMC3161734/ /pubmed/21887226 http://dx.doi.org/10.1371/journal.pone.0023026 Text en Schäuble et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Schäuble, Sascha
Heiland, Ines
Voytsekh, Olga
Mittag, Maria
Schuster, Stefan
Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii
title Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii
title_full Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii
title_fullStr Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii
title_full_unstemmed Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii
title_short Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii
title_sort predicting the physiological role of circadian metabolic regulation in the green alga chlamydomonas reinhardtii
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161734/
https://www.ncbi.nlm.nih.gov/pubmed/21887226
http://dx.doi.org/10.1371/journal.pone.0023026
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