Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

BACKGROUND: We previously showed that activation of the bile salt nuclear receptor Farnesoid X Receptor (FXR) protects against intestinal inflammation in mice. Reciprocally, these inflammatory mediators may decrease FXR activation. We investigated whether FXR activation is repressed in the ileum and...

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Detalles Bibliográficos
Autores principales: Nijmeijer, Rian M., Gadaleta, Raffaella M., van Mil, Saskia W. C., van Bodegraven, Adriaan A., Crusius, J. Bart A., Dijkstra, Gerard, Hommes, Daan W., de Jong, Dirk J., Stokkers, Pieter C. F., Verspaget, Hein W., Weersma, Rinse K., van der Woude, C. Janneke, Stapelbroek, Janneke M., Schipper, Marguerite E. I., Wijmenga, Cisca, van Erpecum, Karel J., Oldenburg, Bas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161760/
https://www.ncbi.nlm.nih.gov/pubmed/21887309
http://dx.doi.org/10.1371/journal.pone.0023745

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