Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway

BACKGROUND: Elevated brain levels of the pleiotropic cytokine interleukin-6, which is mainly secreted from activated local astrocytes, contribute to pathological events including neuroinflammation and neurodegeneration. Thus, inhibition of pathological IL-6 expression provides a rationale strategy f...

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Detalles Bibliográficos
Autores principales: Schulz, Ingo, Engel, Claudia, Niestroj, André J, Zeitschel, Ulrike, Menge, Katja, Kehlen, Astrid, Meyer, Antje, Roßner, Steffen, Demuth, Hans-Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161871/
https://www.ncbi.nlm.nih.gov/pubmed/21801384
http://dx.doi.org/10.1186/1742-2094-8-86

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