Cargando…

Enhanced inhibitory synaptic transmission in the spinal dorsal horn mediates antinociceptive effects of TC-2559

BACKGROUND: TC-2559 is a selective α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist and α4β2 nAChR activation has been related to antinociception. The aim of this study is to investigate the analgesic effect of TC-2559 and its underlying spinal mechanisms. RESULTS: 1) In vivo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Long-Zhen, Han, Lei, Fan, Jing, Huang, Lan-Ting, Peng, Li-Chao, Wang, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161881/ https://www.ncbi.nlm.nih.gov/pubmed/21816108 http://dx.doi.org/10.1186/1744-8069-7-56

Ejemplares similares

Anti-allodynic and promotive effect on inhibitory synaptic transmission of riluzole in rat spinal dorsal horn
por: Taiji, Ryo, et al.
Publicado: (2021)

Modulation of GABAergic Synaptic Transmission by NMDA Receptors in the Dorsal Horn of the Spinal Cord
por: Leonardon, Benjamin, et al.
Publicado: (2022)

The activation of nicotinic acetylcholine receptors enhances the inhibitory synaptic transmission in the deep dorsal horn neurons of the adult rat spinal cord
por: Takeda, Daisuke, et al.
Publicado: (2007)

Xenon inhibits excitatory but not inhibitory transmission in rat spinal cord dorsal horn neurons
por: Georgiev, Stefan K, et al.
Publicado: (2010)

Inhibitory coupling between inhibitory interneurons in the spinal cord dorsal horn
por: Labrakakis, Charalampos, et al.
Publicado: (2009)

In vivo patch-clamp analysis of the antinociceptive actions of TRPA1 activation in the spinal dorsal horn
por: Yamanaka, Manabu, et al.
Publicado: (2015)

Targeted anatomical and functional identification of antinociceptive and pronociceptive serotonergic neurons that project to the spinal dorsal horn
por: Ganley, Robert Philip, et al.
Publicado: (2023)

Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes
por: Zhang, Haijun, et al.
Publicado: (2009)

Identification of 5-HT receptor subtypes enhancing inhibitory transmission in the rat spinal dorsal horn in vitro
por: Xie, Du-Jie, et al.
Publicado: (2012)

Endomorphin-2 Decreases Excitatory Synaptic Transmission in the Spinal Ventral Horn of the Rat
por: Wu, Zhen-Yu, et al.
Publicado: (2017)

Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn
por: Heles, Mario, et al.
Publicado: (2021)

Pain-related synaptic plasticity in spinal dorsal horn neurons: role of CGRP
por: Bird, Gary C, et al.
Publicado: (2006)

Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn
por: Punnakkal, Pradeep, et al.
Publicado: (2014)

Synaptic Targets of Glycinergic Neurons in Laminae I–III of the Spinal Dorsal Horn
por: Miranda, Camila Oliveira, et al.
Publicado: (2023)

The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn
por: Abraira, Victoria E., et al.
Publicado: (2017)

Different forms of glycine- and GABA(A)-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons
por: Anderson, Wayne B, et al.
Publicado: (2009)

ST2-Conditioned Medium Fosters Dorsal Horn Cell Excitability and Synaptic Transmission in Cultured Mouse Spinal Cord
por: Juárez, Esri H., et al.
Publicado: (2023)

Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture
por: Hendrich, Janek, et al.
Publicado: (2012)

Dissociation of μ- and δ-opioid inhibition of glutamatergic synaptic transmission in superficial dorsal horn
por: Wrigley, Paul J, et al.
Publicado: (2010)

Age-dependent decrease in inhibitory drive on the excitatory superficial spinal dorsal horn neurons
por: Rayi, Prudhvi Raj, et al.
Publicado: (2023)

Mitochondrial superoxide increases excitatory synaptic strength in spinal dorsal horn neurons of neuropathic mice
por: Bae, Chilman, et al.
Publicado: (2018)

A Quantitative Study of Inhibitory Interneurons in Laminae I-III of the Mouse Spinal Dorsal Horn
por: Polgár, Erika, et al.
Publicado: (2013)

Functional differences between neurochemically defined populations of inhibitory interneurons in the rat spinal dorsal horn()
por: Polgár, Erika, et al.
Publicado: (2013)

Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn
por: Lee, Kwan Yeop, et al.
Publicado: (2019)

Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold
por: Albisetti, Gioele W., et al.
Publicado: (2023)

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling
por: Boyle, Kieran A, et al.
Publicado: (2023)

Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization
por: Ferrini, Francesco, et al.
Publicado: (2020)

Neuron Type-Dependent Synaptic Activity in the Spinal Dorsal Horn of Opioid-Induced Hyperalgesia Mouse Model
por: Kearns, Austin, et al.
Publicado: (2021)

Diversity of inhibitory and excitatory parvalbumin interneuron circuits in the dorsal horn
por: Gradwell, Mark A., et al.
Publicado: (2022)

2559. Antibiotic-induced Bartter-like syndrome - A Systematic Review
por: Priyadarshi, Megha, et al.
Publicado: (2023)

5-HT(7) Receptors Regulate Excitatory-Inhibitory Balance in Mouse Spinal Cord Dorsal Horn
por: Comitato, Antonella, et al.
Publicado: (2022)

Morphological investigations of endomorphin-2 and spinoparabrachial projection neurons in the spinal dorsal horn of the rat
por: Yin, Jun-Bin, et al.
Publicado: (2022)

Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn
por: Chamessian, Alexander, et al.
Publicado: (2018)

Expression of cholecystokinin by neurons in mouse spinal dorsal horn
por: Gutierrez‐Mecinas, Maria, et al.
Publicado: (2019)

Elevated serotonin in mouse spinal dorsal horn is pronociceptive
por: Cramer, Nathan, et al.
Publicado: (2023)

Distinct forms of synaptic inhibition and neuromodulation regulate calretinin-positive neuron excitability in the spinal cord dorsal horn
por: Smith, K.M., et al.
Publicado: (2016)

2559. A Novel Approach to Interprofessional Education to Expand HIV Workforce Pipeline
por: Leedy, Nicole, et al.
Publicado: (2019)

PB2559: VARIEGATE PORPHYRIA CONFIRMED BY NGS AND TREATED WITH GIVOSIRAN - CASE PRESENTATION
por: Georgescu, Georgeta Daniela
Publicado: (2023)

A combined electrophysiological and morphological study of neuropeptide Y–expressing inhibitory interneurons in the spinal dorsal horn of the mouse
por: Iwagaki, Noboru, et al.
Publicado: (2015)

A quantitative study of neurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the mouse spinal cord
por: Boyle, Kieran A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_f9ored8bpimc82hbspahedgh6a