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Natural Polymorphism in BUL2 Links Cellular Amino Acid Availability with Chronological Aging and Telomere Maintenance in Yeast

Aging and longevity are considered to be highly complex genetic traits. In order to gain insight into aging as a polygenic trait, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard strain RM11 and a laboratory strain S288c, to identify quantitative trait loci tha...

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Detalles Bibliográficos
Autores principales: Kwan, Elizabeth X., Foss, Eric, Kruglyak, Leonid, Bedalov, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161923/
https://www.ncbi.nlm.nih.gov/pubmed/21901113
http://dx.doi.org/10.1371/journal.pgen.1002250