Predisposition to Cancer Caused by Genetic and Functional Defects of Mammalian Atad5

ATAD5, the human ortholog of yeast Elg1, plays a role in PCNA deubiquitination. Since PCNA modification is important to regulate DNA damage bypass, ATAD5 may be important for suppression of genomic instability in mammals in vivo. To test this hypothesis, we generated heterozygous (Atad5(+/m)) mice t...

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Detalles Bibliográficos
Autores principales: Bell, Daphne W., Sikdar, Nilabja, Lee, Kyoo-young, Price, Jessica C., Chatterjee, Raghunath, Park, Hee-Dong, Fox, Jennifer, Ishiai, Masamichi, Rudd, Meghan L., Pollock, Lana M., Fogoros, Sarah K., Mohamed, Hassan, Hanigan, Christin L., Zhang, Suiyuan, Cruz, Pedro, Renaud, Gabriel, Hansen, Nancy F., Cherukuri, Praveen F., Borate, Bhavesh, McManus, Kirk J., Stoepel, Jan, Sipahimalani, Payal, Godwin, Andrew K., Sgroi, Dennis C., Merino, Maria J., Elliot, Gene, Elkahloun, Abdel, Vinson, Charles, Takata, Minoru, Mullikin, James C., Wolfsberg, Tyra G., Hieter, Philip, Lim, Dae-Sik, Myung, Kyungjae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161924/
https://www.ncbi.nlm.nih.gov/pubmed/21901109
http://dx.doi.org/10.1371/journal.pgen.1002245

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