A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression

BACKGROUND: A novel anticancer drug 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd, TAS106) has been shown to radiosensitize tumor cells and to improve the therapeutic efficiency of X-irradiation. However, the effect of TAS106 on cellular DNA repair capacity has not been elucidated. Our aim i...

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Detalles Bibliográficos
Autores principales: Meike, Shunsuke, Yamamori, Tohru, Yasui, Hironobu, Eitaki, Masato, Matsuda, Akira, Morimatsu, Masami, Fukushima, Masakazu, Yamasaki, Yasundo, Inanami, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161955/
https://www.ncbi.nlm.nih.gov/pubmed/21798026
http://dx.doi.org/10.1186/1476-4598-10-92

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