Iron homeostasis—Achilles’ heel of Aspergillus fumigatus?

The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron. These metabolic changes depend mainly on the transcription factor HapX. Consiste...

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Detalles Bibliográficos
Autores principales: Schrettl, Markus, Haas, Hubertus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Current Biology 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162135/
https://www.ncbi.nlm.nih.gov/pubmed/21724450
http://dx.doi.org/10.1016/j.mib.2011.06.002
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author Schrettl, Markus
Haas, Hubertus
author_facet Schrettl, Markus
Haas, Hubertus
author_sort Schrettl, Markus
collection PubMed
description The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron. These metabolic changes depend mainly on the transcription factor HapX. Consistent with the crucial role of iron in pathophysiology, genetic inactivation of either HapX or the siderophore system attenuates virulence of A. fumigatus in a murine model of aspergillosis. The differences in iron handling between mammals and fungi might serve to improve therapy and diagnosis of fungal infections.
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spelling pubmed-31621352011-09-29 Iron homeostasis—Achilles’ heel of Aspergillus fumigatus? Schrettl, Markus Haas, Hubertus Curr Opin Microbiol Article The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron. These metabolic changes depend mainly on the transcription factor HapX. Consistent with the crucial role of iron in pathophysiology, genetic inactivation of either HapX or the siderophore system attenuates virulence of A. fumigatus in a murine model of aspergillosis. The differences in iron handling between mammals and fungi might serve to improve therapy and diagnosis of fungal infections. Current Biology 2011-08 /pmc/articles/PMC3162135/ /pubmed/21724450 http://dx.doi.org/10.1016/j.mib.2011.06.002 Text en © 2011 Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Article
Schrettl, Markus
Haas, Hubertus
Iron homeostasis—Achilles’ heel of Aspergillus fumigatus?
title Iron homeostasis—Achilles’ heel of Aspergillus fumigatus?
title_full Iron homeostasis—Achilles’ heel of Aspergillus fumigatus?
title_fullStr Iron homeostasis—Achilles’ heel of Aspergillus fumigatus?
title_full_unstemmed Iron homeostasis—Achilles’ heel of Aspergillus fumigatus?
title_short Iron homeostasis—Achilles’ heel of Aspergillus fumigatus?
title_sort iron homeostasis—achilles’ heel of aspergillus fumigatus?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162135/
https://www.ncbi.nlm.nih.gov/pubmed/21724450
http://dx.doi.org/10.1016/j.mib.2011.06.002
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