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Pharmacokinetics of aprepitant and dexamethasone after administration of chemotherapeutic agents and effects of plasma substance P concentration on chemotherapy-induced nausea and vomiting in Japanese cancer patients

PURPOSE: This study was conducted to determine the pharmacokinetics of aprepitant and dexamethasone as well as the relationship between the plasma concentration of substance P and nausea/vomiting in Japanese cancer patients. METHODS: After administration of aprepitant (125/80 mg group [10 patients]:...

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Detalles Bibliográficos
Autores principales:	Takahashi, Toshiaki, Nakamura, Yukiko, Tsuya, Asuka, Murakami, Haruyasu, Endo, Masahiro, Yamamoto, Nobuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162145/ https://www.ncbi.nlm.nih.gov/pubmed/21125277 http://dx.doi.org/10.1007/s00280-010-1519-2

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