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Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy?
BACKGROUND: Cryotherapy has been accepted as the mainstay in treating periunugal and palmoplantar warts. The major drawback of cryotherapy is the requirement of several unbearably painful treatment sessions. OBJECTIVE: This study aims to assess the efficacy of immunotherapy in viral wart treatment,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Dermatological Association; The Korean Society for Investigative Dermatology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162255/ https://www.ncbi.nlm.nih.gov/pubmed/21909196 http://dx.doi.org/10.5021/ad.2011.23.3.282 |
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author | Choi, Jae Woo Cho, Soyun Lee, Jong Hee |
author_facet | Choi, Jae Woo Cho, Soyun Lee, Jong Hee |
author_sort | Choi, Jae Woo |
collection | PubMed |
description | BACKGROUND: Cryotherapy has been accepted as the mainstay in treating periunugal and palmoplantar warts. The major drawback of cryotherapy is the requirement of several unbearably painful treatment sessions. OBJECTIVE: This study aims to assess the efficacy of immunotherapy in viral wart treatment, as an adjunctive method to cryotherapy. METHODS: Retrospective chart review was performed on 124 patients visiting the hospital from January to December 2009 for the treatment of periungual and plantar warts. We analyzed the number of cryotherapy sessions necessary for treating warts and assessed the clinical benefits from the addition of other treatment modalities, by adjusting the various confounding factors. RESULTS: Of the 124 investigated patients, immunotherapy with diphenylcyclopropenone (DPCP) was performed in 14 patients (11%), together with cryotherapy. After adjusting the factors related to the therapeutic difficulties of wart, the average number of cryotherapy sessions for the immunotherapy-combined group was significantly lower (3.58±1.25) than that for the cryotherapy only group (5.10±0.44) (p=0.026). However, there were no differences in the number of treatment sessions of cryotherapy when topical 5-FU/salicylic acid agents were added to the treatment. CONCLUSION: Immunotherapy may be a successful adjuvant to cryotherapy in reducing the number of agonizing cryotherapy sessions. |
format | Online Article Text |
id | pubmed-3162255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Korean Dermatological Association; The Korean Society for Investigative Dermatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-31622552011-09-09 Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy? Choi, Jae Woo Cho, Soyun Lee, Jong Hee Ann Dermatol Original Article BACKGROUND: Cryotherapy has been accepted as the mainstay in treating periunugal and palmoplantar warts. The major drawback of cryotherapy is the requirement of several unbearably painful treatment sessions. OBJECTIVE: This study aims to assess the efficacy of immunotherapy in viral wart treatment, as an adjunctive method to cryotherapy. METHODS: Retrospective chart review was performed on 124 patients visiting the hospital from January to December 2009 for the treatment of periungual and plantar warts. We analyzed the number of cryotherapy sessions necessary for treating warts and assessed the clinical benefits from the addition of other treatment modalities, by adjusting the various confounding factors. RESULTS: Of the 124 investigated patients, immunotherapy with diphenylcyclopropenone (DPCP) was performed in 14 patients (11%), together with cryotherapy. After adjusting the factors related to the therapeutic difficulties of wart, the average number of cryotherapy sessions for the immunotherapy-combined group was significantly lower (3.58±1.25) than that for the cryotherapy only group (5.10±0.44) (p=0.026). However, there were no differences in the number of treatment sessions of cryotherapy when topical 5-FU/salicylic acid agents were added to the treatment. CONCLUSION: Immunotherapy may be a successful adjuvant to cryotherapy in reducing the number of agonizing cryotherapy sessions. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2011-08 2011-08-06 /pmc/articles/PMC3162255/ /pubmed/21909196 http://dx.doi.org/10.5021/ad.2011.23.3.282 Text en Copyright © 2011 Korean Dermatological Association; The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Choi, Jae Woo Cho, Soyun Lee, Jong Hee Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy? |
title | Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy? |
title_full | Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy? |
title_fullStr | Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy? |
title_full_unstemmed | Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy? |
title_short | Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy? |
title_sort | does immunotherapy of viral warts provide beneficial effects when it is combined with conventional therapy? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162255/ https://www.ncbi.nlm.nih.gov/pubmed/21909196 http://dx.doi.org/10.5021/ad.2011.23.3.282 |
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