A Case of Cutaneous Side Effect of Methotrexate Mimicking Behçet's Disease

Methotrexate (MTX) is an antimetabolite which interferes with DNA synthesis, and it is used for the treatment of moderate to severe psoriasis, atopic dermatitis and a wide variety of cutaneous diseases. Although many adverse effects of MTX, including cutaneous ulcerations, have been documented, mult...

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Autores principales: Lee, Hyun Jae, Hong, Soon Kwon, Seo, Jong Keun, Lee, Deborah, Sung, Ho Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Dermatological Association; The Korean Society for Investigative Dermatology 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162281/
https://www.ncbi.nlm.nih.gov/pubmed/21909222
http://dx.doi.org/10.5021/ad.2011.23.3.412
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author Lee, Hyun Jae
Hong, Soon Kwon
Seo, Jong Keun
Lee, Deborah
Sung, Ho Suk
author_facet Lee, Hyun Jae
Hong, Soon Kwon
Seo, Jong Keun
Lee, Deborah
Sung, Ho Suk
author_sort Lee, Hyun Jae
collection PubMed
description Methotrexate (MTX) is an antimetabolite which interferes with DNA synthesis, and it is used for the treatment of moderate to severe psoriasis, atopic dermatitis and a wide variety of cutaneous diseases. Although many adverse effects of MTX, including cutaneous ulcerations, have been documented, multifocal mucosal ulceration mimicking Behçet's disease has not been reported. In our case, a 63-year-old female presented with oral, vaginal ulcer and multiple purpuric patches on both legs. Considering patient's clinical course and histopathologic findings, we presumed that these reactions may be the side effect of MTX administered for treatment of necrotizing scleritis. Herein we report the cutaneous side effect of MTX that manifested clinically like Behçet's disease.
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spelling pubmed-31622812011-09-09 A Case of Cutaneous Side Effect of Methotrexate Mimicking Behçet's Disease Lee, Hyun Jae Hong, Soon Kwon Seo, Jong Keun Lee, Deborah Sung, Ho Suk Ann Dermatol Case Report Methotrexate (MTX) is an antimetabolite which interferes with DNA synthesis, and it is used for the treatment of moderate to severe psoriasis, atopic dermatitis and a wide variety of cutaneous diseases. Although many adverse effects of MTX, including cutaneous ulcerations, have been documented, multifocal mucosal ulceration mimicking Behçet's disease has not been reported. In our case, a 63-year-old female presented with oral, vaginal ulcer and multiple purpuric patches on both legs. Considering patient's clinical course and histopathologic findings, we presumed that these reactions may be the side effect of MTX administered for treatment of necrotizing scleritis. Herein we report the cutaneous side effect of MTX that manifested clinically like Behçet's disease. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2011-08 2011-08-18 /pmc/articles/PMC3162281/ /pubmed/21909222 http://dx.doi.org/10.5021/ad.2011.23.3.412 Text en Copyright © 2011 Korean Dermatological Association; The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Hyun Jae
Hong, Soon Kwon
Seo, Jong Keun
Lee, Deborah
Sung, Ho Suk
A Case of Cutaneous Side Effect of Methotrexate Mimicking Behçet's Disease
title A Case of Cutaneous Side Effect of Methotrexate Mimicking Behçet's Disease
title_full A Case of Cutaneous Side Effect of Methotrexate Mimicking Behçet's Disease
title_fullStr A Case of Cutaneous Side Effect of Methotrexate Mimicking Behçet's Disease
title_full_unstemmed A Case of Cutaneous Side Effect of Methotrexate Mimicking Behçet's Disease
title_short A Case of Cutaneous Side Effect of Methotrexate Mimicking Behçet's Disease
title_sort case of cutaneous side effect of methotrexate mimicking behçet's disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162281/
https://www.ncbi.nlm.nih.gov/pubmed/21909222
http://dx.doi.org/10.5021/ad.2011.23.3.412
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