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Osteoprotegerin and coronary artery disease in type 2 diabetic patients with microalbuminuria

OBJECTIVE: Plasma osteoprotegerin (P-OPG) is an independent predictor of cardiovascular disease in diabetic and other populations. OPG is a bone-related glycopeptide produced by vascular smooth muscle cells and increased P-OPG may reflect arterial damage. We investigated the correlation between P-OP...

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Autores principales: Reinhard, Henrik, Nybo, Mads, Hansen, Peter R, Wiinberg, Niels, Kjær, Andreas, Petersen, Claus L, Winther, Kaj, Parving, Hans-Henrik, Rasmussen, Lars M, Rossing, Peter, Jacobsen, Peter K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162489/
https://www.ncbi.nlm.nih.gov/pubmed/21801376
http://dx.doi.org/10.1186/1475-2840-10-70
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author Reinhard, Henrik
Nybo, Mads
Hansen, Peter R
Wiinberg, Niels
Kjær, Andreas
Petersen, Claus L
Winther, Kaj
Parving, Hans-Henrik
Rasmussen, Lars M
Rossing, Peter
Jacobsen, Peter K
author_facet Reinhard, Henrik
Nybo, Mads
Hansen, Peter R
Wiinberg, Niels
Kjær, Andreas
Petersen, Claus L
Winther, Kaj
Parving, Hans-Henrik
Rasmussen, Lars M
Rossing, Peter
Jacobsen, Peter K
author_sort Reinhard, Henrik
collection PubMed
description OBJECTIVE: Plasma osteoprotegerin (P-OPG) is an independent predictor of cardiovascular disease in diabetic and other populations. OPG is a bone-related glycopeptide produced by vascular smooth muscle cells and increased P-OPG may reflect arterial damage. We investigated the correlation between P-OPG and coronary artery disease (CAD) in asymptomatic type 2 diabetic patients with microalbuminuria. METHODS: P-OPG was measured in 200 asymptomatic diabetic patients without known cardiac disease. Patients with P-NT-proBNP >45.2 ng/l and/or coronary calcium score (CCS) ≥400 were stratified as high risk of CAD (n = 133), and all other patients as low risk patients (n = 67). High risk patients were examined by myocardial perfusion imaging (MPI; n = 109), and/or CT-angiography (n = 20), and/or coronary angiography (CAG; n = 86). Significant CAD was defined by presence of significant myocardial perfusion defects at MPI and/or >70% coronary artery stenosis at CAG. RESULTS: Significant CAD was demonstrated in 70 of the high risk patients and of these 23 patients had >70% coronary artery stenosis at CAG. Among high risk patients, increased P-OPG was an independent predictor of significant CAD (adjusted odds ratio [CI] 3.11 [1.01-19.54] and 3.03 [1.00-9.18] for second and third tertile vs.first tertile P-OPG, respectively) and remained so after adjustments for NT-proBNP and CCS. High P-OPG was also associated with presence of >70% coronary artery stenosis(adjusted odds ratio 14.20 [1.35-148.92] for third vs. first tertile P-OPG), and 91% of patients with low (first tertile) P-OPG did not have >70% coronary artery stenosis. CONCLUSIONS: Elevated P-OPG is an independent predictor of the presence of CAD in asymptomatic type 2 diabetic patients with microalbuminuria.
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spelling pubmed-31624892011-08-27 Osteoprotegerin and coronary artery disease in type 2 diabetic patients with microalbuminuria Reinhard, Henrik Nybo, Mads Hansen, Peter R Wiinberg, Niels Kjær, Andreas Petersen, Claus L Winther, Kaj Parving, Hans-Henrik Rasmussen, Lars M Rossing, Peter Jacobsen, Peter K Cardiovasc Diabetol Original Investigation OBJECTIVE: Plasma osteoprotegerin (P-OPG) is an independent predictor of cardiovascular disease in diabetic and other populations. OPG is a bone-related glycopeptide produced by vascular smooth muscle cells and increased P-OPG may reflect arterial damage. We investigated the correlation between P-OPG and coronary artery disease (CAD) in asymptomatic type 2 diabetic patients with microalbuminuria. METHODS: P-OPG was measured in 200 asymptomatic diabetic patients without known cardiac disease. Patients with P-NT-proBNP >45.2 ng/l and/or coronary calcium score (CCS) ≥400 were stratified as high risk of CAD (n = 133), and all other patients as low risk patients (n = 67). High risk patients were examined by myocardial perfusion imaging (MPI; n = 109), and/or CT-angiography (n = 20), and/or coronary angiography (CAG; n = 86). Significant CAD was defined by presence of significant myocardial perfusion defects at MPI and/or >70% coronary artery stenosis at CAG. RESULTS: Significant CAD was demonstrated in 70 of the high risk patients and of these 23 patients had >70% coronary artery stenosis at CAG. Among high risk patients, increased P-OPG was an independent predictor of significant CAD (adjusted odds ratio [CI] 3.11 [1.01-19.54] and 3.03 [1.00-9.18] for second and third tertile vs.first tertile P-OPG, respectively) and remained so after adjustments for NT-proBNP and CCS. High P-OPG was also associated with presence of >70% coronary artery stenosis(adjusted odds ratio 14.20 [1.35-148.92] for third vs. first tertile P-OPG), and 91% of patients with low (first tertile) P-OPG did not have >70% coronary artery stenosis. CONCLUSIONS: Elevated P-OPG is an independent predictor of the presence of CAD in asymptomatic type 2 diabetic patients with microalbuminuria. BioMed Central 2011-07-29 /pmc/articles/PMC3162489/ /pubmed/21801376 http://dx.doi.org/10.1186/1475-2840-10-70 Text en Copyright ©2011 Reinhard et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Investigation
Reinhard, Henrik
Nybo, Mads
Hansen, Peter R
Wiinberg, Niels
Kjær, Andreas
Petersen, Claus L
Winther, Kaj
Parving, Hans-Henrik
Rasmussen, Lars M
Rossing, Peter
Jacobsen, Peter K
Osteoprotegerin and coronary artery disease in type 2 diabetic patients with microalbuminuria
title Osteoprotegerin and coronary artery disease in type 2 diabetic patients with microalbuminuria
title_full Osteoprotegerin and coronary artery disease in type 2 diabetic patients with microalbuminuria
title_fullStr Osteoprotegerin and coronary artery disease in type 2 diabetic patients with microalbuminuria
title_full_unstemmed Osteoprotegerin and coronary artery disease in type 2 diabetic patients with microalbuminuria
title_short Osteoprotegerin and coronary artery disease in type 2 diabetic patients with microalbuminuria
title_sort osteoprotegerin and coronary artery disease in type 2 diabetic patients with microalbuminuria
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162489/
https://www.ncbi.nlm.nih.gov/pubmed/21801376
http://dx.doi.org/10.1186/1475-2840-10-70
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