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The coupling of pathways and processes through shared components
BACKGROUND: The coupling of pathways and processes through shared components is being increasingly recognised as a common theme which occurs in many cell signalling contexts, in which it plays highly non-trivial roles. RESULTS: In this paper we develop a basic modelling and systems framework in a ge...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162518/ https://www.ncbi.nlm.nih.gov/pubmed/21714894 http://dx.doi.org/10.1186/1752-0509-5-103 |
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author | Seaton, Daniel D Krishnan, J |
author_facet | Seaton, Daniel D Krishnan, J |
author_sort | Seaton, Daniel D |
collection | PubMed |
description | BACKGROUND: The coupling of pathways and processes through shared components is being increasingly recognised as a common theme which occurs in many cell signalling contexts, in which it plays highly non-trivial roles. RESULTS: In this paper we develop a basic modelling and systems framework in a general setting for understanding the coupling of processes and pathways through shared components. Our modelling framework starts with the interaction of two components with a common third component and includes production and degradation of all these components. We analyze the signal processing in our model to elucidate different aspects of the coupling. We show how different kinds of responses, including "ultrasensitive" and adaptive responses, may occur in this setting. We then build on the basic model structure and examine the effects of additional control regulation, switch-like signal processing, and spatial signalling. In the process, we identify a way in which allosteric regulation may contribute to signalling specificity, and how competitive effects may allow an enzyme to robustly coordinate and time the activation of parallel pathways. CONCLUSIONS: We have developed and analyzed a common systems platform for examining the effects of coupling of processes through shared components. This can be the basis for subsequent expansion and understanding the many biologically observed variations on this common theme. |
format | Online Article Text |
id | pubmed-3162518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31625182011-08-27 The coupling of pathways and processes through shared components Seaton, Daniel D Krishnan, J BMC Syst Biol Research Article BACKGROUND: The coupling of pathways and processes through shared components is being increasingly recognised as a common theme which occurs in many cell signalling contexts, in which it plays highly non-trivial roles. RESULTS: In this paper we develop a basic modelling and systems framework in a general setting for understanding the coupling of processes and pathways through shared components. Our modelling framework starts with the interaction of two components with a common third component and includes production and degradation of all these components. We analyze the signal processing in our model to elucidate different aspects of the coupling. We show how different kinds of responses, including "ultrasensitive" and adaptive responses, may occur in this setting. We then build on the basic model structure and examine the effects of additional control regulation, switch-like signal processing, and spatial signalling. In the process, we identify a way in which allosteric regulation may contribute to signalling specificity, and how competitive effects may allow an enzyme to robustly coordinate and time the activation of parallel pathways. CONCLUSIONS: We have developed and analyzed a common systems platform for examining the effects of coupling of processes through shared components. This can be the basis for subsequent expansion and understanding the many biologically observed variations on this common theme. BioMed Central 2011-06-29 /pmc/articles/PMC3162518/ /pubmed/21714894 http://dx.doi.org/10.1186/1752-0509-5-103 Text en Copyright ©2011 Seaton and Krishnan; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Seaton, Daniel D Krishnan, J The coupling of pathways and processes through shared components |
title | The coupling of pathways and processes through shared components |
title_full | The coupling of pathways and processes through shared components |
title_fullStr | The coupling of pathways and processes through shared components |
title_full_unstemmed | The coupling of pathways and processes through shared components |
title_short | The coupling of pathways and processes through shared components |
title_sort | coupling of pathways and processes through shared components |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162518/ https://www.ncbi.nlm.nih.gov/pubmed/21714894 http://dx.doi.org/10.1186/1752-0509-5-103 |
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