GagCM9-Specific CD8(+) T Cells Expressing Limited Public TCR Clonotypes Do Not Suppress SIV Replication In Vivo

Several lines of evidence suggest that HIV/SIV-specific CD8(+) T cells play a critical role in the control of viral replication. Recently we observed high levels of viremia in Indian rhesus macaques vaccinated with a segment of SIVmac239 Gag (Gag(45–269)) that were subsequently infected with SIVsmE6...

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Detalles Bibliográficos
Autores principales: Vojnov, Lara, Martins, Mauricio A., Almeida, Jorge R., Ende, Zachary, Rakasz, Eva G., Reynolds, Matthew R., Leon, Enrique J., Weisgrau, Kim L., Burwitz, Benjamin J., Folkvord, Joy M., Veloso de Santana, Marlon G., Costa Neves, Patrícia C., Connick, Elizabeth, Skinner, Pamela J., Gostick, Emma, O'Connor, David H., Wilson, Nancy A., Bonaldo, Myrna C., Galler, Ricardo, Price, David A., Douek, Danny C., Watkins, David I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162554/
https://www.ncbi.nlm.nih.gov/pubmed/21887264
http://dx.doi.org/10.1371/journal.pone.0023515

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