Cargando…

NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene

BACKGROUND: Several predisposition loci for hereditary prostate cancer (HPC) have been suggested, including HPCX1 at Xq27-q28, but due to the complex structure of the region, the susceptibility gene has not yet been identified. METHODS: In this study, nonsense-mediated mRNA decay (NMD) inhibition wa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mattila, Henna, Schindler, Martin, Isotalo, Jarkko, Ikonen, Tarja, Vihinen, Mauno, Oja, Hannu, Tammela, Teuvo LJ, Wahlfors, Tiina, Schleutker, Johanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162583/ https://www.ncbi.nlm.nih.gov/pubmed/21810217 http://dx.doi.org/10.1186/1471-2407-11-327

Ejemplares similares

MiRNA Profiles in Lymphoblastoid Cell Lines of Finnish Prostate Cancer Families
por: Fischer, Daniel, et al.
Publicado: (2015)

PALB2 variants in hereditary and unselected Finnish Prostate cancer cases
por: Pakkanen, Sanna, et al.
Publicado: (2009)

Inherited DNA Repair Gene Mutations in Men with Lethal Prostate Cancer
por: Rantapero, Tommi, et al.
Publicado: (2020)

Contribution of ARLTS1 Cys148Arg (T442C) Variant with Prostate Cancer Risk and ARLTS1 Function in Prostate Cancer Cells
por: Siltanen, Sanna, et al.
Publicado: (2011)

Establishment of MAGEC2‐knockout cells and functional investigation of MAGEC2 in tumor cells
por: Wang, Jingjing, et al.
Publicado: (2016)

Assessing Interactions of Two Loci (rs4242382 and rs10486567) in Familial Prostate Cancer: Statistical Evaluation of Epistasis
por: Chen, Li-Sheng, et al.
Publicado: (2014)

Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer
por: Sjöblom, Liisa, et al.
Publicado: (2016)

Novel prostate cancer susceptibility gene SP6 predisposes patients to aggressive disease
por: Sipeky, Csilla, et al.
Publicado: (2021)

Loss of MAGEC3 Expression Is Associated with Prognosis in Advanced Ovarian Cancers
por: Ellegate, James, et al.
Publicado: (2022)

The Performance of MAGEC X Spine Rods: A Comparative Retrieval Study
por: Tognini, Martina, et al.
Publicado: (2022)

Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals
por: Kuusisto, Kirsi M, et al.
Publicado: (2011)

MAGEC2, an epithelial-mesenchymal transition inducer, is associated with breast cancer metastasis
por: Yang, Fan, et al.
Publicado: (2014)

The impact and surgeon perceptions of the suspension of the CE certification of MAGEC devices on clinical practice
por: Hothi, Harry
Publicado: (2022)

Sublaminar Band Fixation Provides Excellent Anchors for MAGEC Rod Distraction Systems
por: Rosenfeld, Samuel R., et al.
Publicado: (2023)

The MAGEC System for Spinal Lengthening in Children with Scoliosis: A NICE Medical Technology Guidance
por: Jenks, Michelle, et al.
Publicado: (2014)

Device-Related Complications Associated with Magec Rod Usage for Distraction-Based Correction of Scoliosis
por: Agarwal, Aakash, et al.
Publicado: (2019)

Combined BRCA2 and MAGEC3 Expression Predict Outcome in Advanced Ovarian Cancers
por: Omole, Emmanuel B., et al.
Publicado: (2022)

Prostate cancer risk prediction using a polygenic risk score
por: Sipeky, Csilla, et al.
Publicado: (2020)

Copy Number Variation Analysis in Familial BRCA1/2-Negative Finnish Breast and Ovarian Cancer
por: Kuusisto, Kirsi M., et al.
Publicado: (2013)

Reducing overdiagnosis by polygenic risk-stratified screening: findings from the Finnish section of the ERSPC
por: Pashayan, Nora, et al.
Publicado: (2015)

Elucidation of the Mechanism of Host NMD Suppression by HTLV-1 Rex: Dissection of Rex to Identify the NMD Inhibitory Domain
por: Nakano, Kazumi, et al.
Publicado: (2022)

ARLTS1 and Prostate Cancer Risk - Analysis of Expression and Regulation
por: Siltanen, Sanna, et al.
Publicado: (2013)

Post-transcriptional regulation of cancer/testis antigen MAGEC2 expression by TRIM28 in tumor cells
por: Song, Xiao, et al.
Publicado: (2018)

MAGEC2 Correlates With Unfavorable Prognosis And Promotes Tumor Development In HCC Via Epithelial-Mesenchymal Transition
por: Gu, Xuefeng, et al.
Publicado: (2019)

How to evaluate performance of prediction methods? Measures and their interpretation in variation effect analysis
por: Vihinen, Mauno
Publicado: (2012)

Variation Ontology for annotation of variation effects and mechanisms
por: Vihinen, Mauno
Publicado: (2014)

Variation ontology: annotator guide
por: Vihinen, Mauno
Publicado: (2014)

Systematics for types and effects of DNA variations
por: Vihinen, Mauno
Publicado: (2018)

Poikilosis – pervasive biological variation
por: Vihinen, Mauno
Publicado: (2020)

Strategy for Disease Diagnosis, Progression Prediction, Risk Group Stratification and Treatment—Case of COVID-19
por: Vihinen, Mauno
Publicado: (2020)

Problems in variation interpretation guidelines and in their implementation in computational tools
por: Vihinen, Mauno
Publicado: (2020)

Guidelines for systematic reporting of sequence alignments
por: Vihinen, Mauno
Publicado: (2020)

Measuring and interpreting pervasive heterogeneity, poikilosis
por: Vihinen, Mauno
Publicado: (2021)

Systematics for types and effects of RNA variations
por: Vihinen, Mauno
Publicado: (2020)

Solubility of proteins
por: Vihinen, Mauno
Publicado: (2020)

When a Synonymous Variant Is Nonsynonymous
por: Vihinen, Mauno
Publicado: (2022)

Generic model for biological regulation
por: Vihinen, Mauno
Publicado: (2022)

Individual Genetic Heterogeneity
por: Vihinen, Mauno
Publicado: (2022)

Systematic errors in annotations of truncations, loss-of-function and synonymous variants
por: Vihinen, Mauno
Publicado: (2023)

A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases
por: Echols, Josh, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5hrqhno5dtkntl79qkqch2d6ta