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Development of angle-resolved low coherence interferometry for clinical detection of dysplasia
This review covers the development of angle-resolved low coherence interferometry (a/LCI) from initial development through clinical application. In the first applications, the approach used a time-domain interferometry scheme and was validated using animal models of carcinogenesis to assess the feas...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162729/ https://www.ncbi.nlm.nih.gov/pubmed/21886457 http://dx.doi.org/10.4103/1477-3163.83935 |
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author | Zhu, Yizheng Terry, Neil G. Wax, Adam |
author_facet | Zhu, Yizheng Terry, Neil G. Wax, Adam |
author_sort | Zhu, Yizheng |
collection | PubMed |
description | This review covers the development of angle-resolved low coherence interferometry (a/LCI) from initial development through clinical application. In the first applications, the approach used a time-domain interferometry scheme and was validated using animal models of carcinogenesis to assess the feasibility of detecting dysplasia in situ. Further development of the approach led to Fourier-domain interferometry schemes with higher throughput and endoscope-compatible probes to enable clinical application. These later implementations have been applied to clinical studies of dysplasia in Barrett's esophagus tissues, a metaplastic tissue type that is associated with an increased risk of esophageal adenocarcinoma. As an alternative to systematic biopsy, the a/LCI approach offers high sensitivity and specificity for detecting dysplasia in these tissues while avoiding the need for tissue removal or exogenous contrast agents. Here, the various implementations of a/LCI are discussed and the results of the preliminary animal experiments and ex vivo human tissue studies are reviewed. A review of a recent in vivo clinical study is also presented. |
format | Online Article Text |
id | pubmed-3162729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-31627292011-08-31 Development of angle-resolved low coherence interferometry for clinical detection of dysplasia Zhu, Yizheng Terry, Neil G. Wax, Adam J Carcinog Review Article This review covers the development of angle-resolved low coherence interferometry (a/LCI) from initial development through clinical application. In the first applications, the approach used a time-domain interferometry scheme and was validated using animal models of carcinogenesis to assess the feasibility of detecting dysplasia in situ. Further development of the approach led to Fourier-domain interferometry schemes with higher throughput and endoscope-compatible probes to enable clinical application. These later implementations have been applied to clinical studies of dysplasia in Barrett's esophagus tissues, a metaplastic tissue type that is associated with an increased risk of esophageal adenocarcinoma. As an alternative to systematic biopsy, the a/LCI approach offers high sensitivity and specificity for detecting dysplasia in these tissues while avoiding the need for tissue removal or exogenous contrast agents. Here, the various implementations of a/LCI are discussed and the results of the preliminary animal experiments and ex vivo human tissue studies are reviewed. A review of a recent in vivo clinical study is also presented. Medknow Publications 2011-08-23 /pmc/articles/PMC3162729/ /pubmed/21886457 http://dx.doi.org/10.4103/1477-3163.83935 Text en © 2011 Zhu. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhu, Yizheng Terry, Neil G. Wax, Adam Development of angle-resolved low coherence interferometry for clinical detection of dysplasia |
title | Development of angle-resolved low coherence interferometry for clinical detection of dysplasia |
title_full | Development of angle-resolved low coherence interferometry for clinical detection of dysplasia |
title_fullStr | Development of angle-resolved low coherence interferometry for clinical detection of dysplasia |
title_full_unstemmed | Development of angle-resolved low coherence interferometry for clinical detection of dysplasia |
title_short | Development of angle-resolved low coherence interferometry for clinical detection of dysplasia |
title_sort | development of angle-resolved low coherence interferometry for clinical detection of dysplasia |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162729/ https://www.ncbi.nlm.nih.gov/pubmed/21886457 http://dx.doi.org/10.4103/1477-3163.83935 |
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