Huntington's Disease: An Immune Perspective

Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brai...

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Detalles Bibliográficos
Autores principales: Nayak, Annapurna, Ansar, Rafia, Verma, Sunil K., Bonifati, Domenico Marco, Kishore, Uday
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163125/
https://www.ncbi.nlm.nih.gov/pubmed/21876800
http://dx.doi.org/10.1155/2011/563784
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author Nayak, Annapurna
Ansar, Rafia
Verma, Sunil K.
Bonifati, Domenico Marco
Kishore, Uday
author_facet Nayak, Annapurna
Ansar, Rafia
Verma, Sunil K.
Bonifati, Domenico Marco
Kishore, Uday
author_sort Nayak, Annapurna
collection PubMed
description Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.
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spelling pubmed-31631252011-08-29 Huntington's Disease: An Immune Perspective Nayak, Annapurna Ansar, Rafia Verma, Sunil K. Bonifati, Domenico Marco Kishore, Uday Neurol Res Int Review Article Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD. Hindawi Publishing Corporation 2011 2011-08-24 /pmc/articles/PMC3163125/ /pubmed/21876800 http://dx.doi.org/10.1155/2011/563784 Text en Copyright © 2011 Annapurna Nayak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nayak, Annapurna
Ansar, Rafia
Verma, Sunil K.
Bonifati, Domenico Marco
Kishore, Uday
Huntington's Disease: An Immune Perspective
title Huntington's Disease: An Immune Perspective
title_full Huntington's Disease: An Immune Perspective
title_fullStr Huntington's Disease: An Immune Perspective
title_full_unstemmed Huntington's Disease: An Immune Perspective
title_short Huntington's Disease: An Immune Perspective
title_sort huntington's disease: an immune perspective
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163125/
https://www.ncbi.nlm.nih.gov/pubmed/21876800
http://dx.doi.org/10.1155/2011/563784
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