The Increased Activity of Liver Lysosomal Lipase in Nonalcoholic Fatty Liver Disease Contributes to the Development of Hepatic Insulin Resistance

We tested the hypothesis that TAG accumulation in the liver induced by short-term high-fat diet (HFD) in rats leads to the dysregulation of endogenous TAG degradation by lysosomal lipase (LIPA) via lysosomal pathway and is causally linked with the onset of hepatic insulin resistance. We found that L...

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Detalles Bibliográficos
Autores principales: Cahova, Monika, Dankova, Helena, Palenickova, Eliska, Papackova, Zuzana, Komers, Radko, Zdychova, Jana, Sticova, Eva, Kazdova, Ludmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163129/
https://www.ncbi.nlm.nih.gov/pubmed/21904679
http://dx.doi.org/10.1155/2012/135723

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