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Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma

BACKGROUND: To evaluate the experience of induction chemotherapy followed by concurrent chemoradiationwith helical tomotherapy (HT) for nasopharyngeal carcinoma (NPC). METHODS: Between August 2006 and December 2009, 28 patients with pathological proven nonmetastatic NPC were enrolled. All patients w...

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Autores principales: Shueng, Pei-Wei, Shen, Bing-Jie, Wu, Le-Jung, Liao, Li-Jen, Hsiao, Chi-Huang, Lin, Yu-Chin, Cheng, Po-Wen, Lo, Wu-Chia, Jen, Yee-Min, Hsieh, Chen-Hsi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163198/
https://www.ncbi.nlm.nih.gov/pubmed/21838917
http://dx.doi.org/10.1186/1748-717X-6-95
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author Shueng, Pei-Wei
Shen, Bing-Jie
Wu, Le-Jung
Liao, Li-Jen
Hsiao, Chi-Huang
Lin, Yu-Chin
Cheng, Po-Wen
Lo, Wu-Chia
Jen, Yee-Min
Hsieh, Chen-Hsi
author_facet Shueng, Pei-Wei
Shen, Bing-Jie
Wu, Le-Jung
Liao, Li-Jen
Hsiao, Chi-Huang
Lin, Yu-Chin
Cheng, Po-Wen
Lo, Wu-Chia
Jen, Yee-Min
Hsieh, Chen-Hsi
author_sort Shueng, Pei-Wei
collection PubMed
description BACKGROUND: To evaluate the experience of induction chemotherapy followed by concurrent chemoradiationwith helical tomotherapy (HT) for nasopharyngeal carcinoma (NPC). METHODS: Between August 2006 and December 2009, 28 patients with pathological proven nonmetastatic NPC were enrolled. All patients were staged as IIB-IVB. Patients were first treated with 2 to 3 cycles of induction chemotherapy with EP-HDFL (Epirubicin, Cisplatin, 5-FU, and Leucovorin). After induction chemotherapy, weekly based PFL was administered concurrent with HT. Radiation consisted of 70 Gy to the planning target volumes of the primary tumor plus any positive nodal disease using 2 Gy per fraction. RESULTS: After completion of induction chemotherapy, the response rates for primary and nodal disease were 96.4% and 80.8%, respectively. With a median follow-up after 33 months (Range, 13-53 months), there have been 2 primary and 1 nodal relapse after completion of radiotherapy. The estimated 3-year progression-free rates for local, regional, locoregional and distant metastasis survival rate were 92.4%, 95.7%, 88.4%, and 78.0%, respectively. The estimated 3-year overall survival was 83.5%. Acute grade 3, 4 toxicities for xerostomia and dermatitis were only 3.6% and 10.7%, respectively. CONCLUSION: HT for locoregionally advanced NPC is feasible and effective in regard to locoregional control with high compliance, even after neoadjuvant chemotherapy. None of out-field or marginal failure noted in the current study confirms the potential benefits of treating NPC patients by image-guided radiation modality. A long-term follow-up study is needed to confirm these preliminary findings.
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spelling pubmed-31631982011-08-29 Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma Shueng, Pei-Wei Shen, Bing-Jie Wu, Le-Jung Liao, Li-Jen Hsiao, Chi-Huang Lin, Yu-Chin Cheng, Po-Wen Lo, Wu-Chia Jen, Yee-Min Hsieh, Chen-Hsi Radiat Oncol Research BACKGROUND: To evaluate the experience of induction chemotherapy followed by concurrent chemoradiationwith helical tomotherapy (HT) for nasopharyngeal carcinoma (NPC). METHODS: Between August 2006 and December 2009, 28 patients with pathological proven nonmetastatic NPC were enrolled. All patients were staged as IIB-IVB. Patients were first treated with 2 to 3 cycles of induction chemotherapy with EP-HDFL (Epirubicin, Cisplatin, 5-FU, and Leucovorin). After induction chemotherapy, weekly based PFL was administered concurrent with HT. Radiation consisted of 70 Gy to the planning target volumes of the primary tumor plus any positive nodal disease using 2 Gy per fraction. RESULTS: After completion of induction chemotherapy, the response rates for primary and nodal disease were 96.4% and 80.8%, respectively. With a median follow-up after 33 months (Range, 13-53 months), there have been 2 primary and 1 nodal relapse after completion of radiotherapy. The estimated 3-year progression-free rates for local, regional, locoregional and distant metastasis survival rate were 92.4%, 95.7%, 88.4%, and 78.0%, respectively. The estimated 3-year overall survival was 83.5%. Acute grade 3, 4 toxicities for xerostomia and dermatitis were only 3.6% and 10.7%, respectively. CONCLUSION: HT for locoregionally advanced NPC is feasible and effective in regard to locoregional control with high compliance, even after neoadjuvant chemotherapy. None of out-field or marginal failure noted in the current study confirms the potential benefits of treating NPC patients by image-guided radiation modality. A long-term follow-up study is needed to confirm these preliminary findings. BioMed Central 2011-08-13 /pmc/articles/PMC3163198/ /pubmed/21838917 http://dx.doi.org/10.1186/1748-717X-6-95 Text en Copyright ©2011 Shueng et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Shueng, Pei-Wei
Shen, Bing-Jie
Wu, Le-Jung
Liao, Li-Jen
Hsiao, Chi-Huang
Lin, Yu-Chin
Cheng, Po-Wen
Lo, Wu-Chia
Jen, Yee-Min
Hsieh, Chen-Hsi
Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma
title Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma
title_full Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma
title_fullStr Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma
title_full_unstemmed Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma
title_short Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma
title_sort concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163198/
https://www.ncbi.nlm.nih.gov/pubmed/21838917
http://dx.doi.org/10.1186/1748-717X-6-95
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