cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

The intracellular regulation of cell death pathways by cIAPs has been enigmatic. Here we show that loss of cIAPs promotes the spontaneous formation of an intracellular platform that activates either apoptosis or necroptosis. This 2 MDa intracellular complex that we designate “Ripoptosome” is necessa...

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Detalles Bibliográficos
Autores principales: Feoktistova, Maria, Geserick, Peter, Kellert, Beate, Dimitrova, Diana Panayotova, Langlais, Claudia, Hupe, Mike, Cain, Kelvin, MacFarlane, Marion, Häcker, Georg, Leverkus, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163271/
https://www.ncbi.nlm.nih.gov/pubmed/21737330
http://dx.doi.org/10.1016/j.molcel.2011.06.011

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