Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents

A series of 2,5,7-trisubstituted pyrimido[4,5-d]pyrimidine cyclin-dependent kinase (CDK2) inhibitors is designed and synthesized. 6-Amino-2-thiouracil is reacted with an aldehyde and thiourea to prepare the pyrimido[4,5-d]-pyrimidines. Alkylation and amination of the latter ones give different amino...

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Autores principales: El-Moghazy, Samir M., Ibrahim, Diaa A., Abdelgawad, Nagwa M., Farag, Nahla A. H., El-Khouly, Ahmad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163380/
https://www.ncbi.nlm.nih.gov/pubmed/21886895
http://dx.doi.org/10.3797/scipharm.1103-16
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author El-Moghazy, Samir M.
Ibrahim, Diaa A.
Abdelgawad, Nagwa M.
Farag, Nahla A. H.
El-Khouly, Ahmad S.
author_facet El-Moghazy, Samir M.
Ibrahim, Diaa A.
Abdelgawad, Nagwa M.
Farag, Nahla A. H.
El-Khouly, Ahmad S.
author_sort El-Moghazy, Samir M.
collection PubMed
description A series of 2,5,7-trisubstituted pyrimido[4,5-d]pyrimidine cyclin-dependent kinase (CDK2) inhibitors is designed and synthesized. 6-Amino-2-thiouracil is reacted with an aldehyde and thiourea to prepare the pyrimido[4,5-d]-pyrimidines. Alkylation and amination of the latter ones give different amino derivatives. These compounds show potent and selective CDK inhibitory activities and inhibit in vitro cellular proliferation in cultured human tumor cells.
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spelling pubmed-31633802011-09-01 Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents El-Moghazy, Samir M. Ibrahim, Diaa A. Abdelgawad, Nagwa M. Farag, Nahla A. H. El-Khouly, Ahmad S. Sci Pharm Research Article A series of 2,5,7-trisubstituted pyrimido[4,5-d]pyrimidine cyclin-dependent kinase (CDK2) inhibitors is designed and synthesized. 6-Amino-2-thiouracil is reacted with an aldehyde and thiourea to prepare the pyrimido[4,5-d]-pyrimidines. Alkylation and amination of the latter ones give different amino derivatives. These compounds show potent and selective CDK inhibitory activities and inhibit in vitro cellular proliferation in cultured human tumor cells. Österreichische Apotheker-Verlagsgesellschaft 2011 2011-05-08 /pmc/articles/PMC3163380/ /pubmed/21886895 http://dx.doi.org/10.3797/scipharm.1103-16 Text en © El-Moghazy et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
El-Moghazy, Samir M.
Ibrahim, Diaa A.
Abdelgawad, Nagwa M.
Farag, Nahla A. H.
El-Khouly, Ahmad S.
Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents
title Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents
title_full Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents
title_fullStr Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents
title_full_unstemmed Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents
title_short Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents
title_sort design, synthesis and biological evaluation of novel pyrimido[4,5-d]pyrimidine cdk2 inhibitors as anti-tumor agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163380/
https://www.ncbi.nlm.nih.gov/pubmed/21886895
http://dx.doi.org/10.3797/scipharm.1103-16
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