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Viruses with More Than 1,000 Genes: Mamavirus, a New Acanthamoeba polyphaga mimivirus Strain, and Reannotation of Mimivirus Genes

The genome sequence of the Mamavirus, a new Acanthamoeba polyphaga mimivirus strain, is reported. With 1,191,693 nt in length and 1,023 predicted protein-coding genes, the Mamavirus has the largest genome among the known viruses. The genomes of the Mamavirus and the previously described Mimivirus ar...

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Autores principales: Colson, Philippe, Yutin, Natalya, Shabalina, Svetlana A., Robert, Catherine, Fournous, Ghislain, La Scola, Bernard, Raoult, Didier, Koonin, Eugene V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163472/
https://www.ncbi.nlm.nih.gov/pubmed/21705471
http://dx.doi.org/10.1093/gbe/evr048
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author Colson, Philippe
Yutin, Natalya
Shabalina, Svetlana A.
Robert, Catherine
Fournous, Ghislain
La Scola, Bernard
Raoult, Didier
Koonin, Eugene V.
author_facet Colson, Philippe
Yutin, Natalya
Shabalina, Svetlana A.
Robert, Catherine
Fournous, Ghislain
La Scola, Bernard
Raoult, Didier
Koonin, Eugene V.
author_sort Colson, Philippe
collection PubMed
description The genome sequence of the Mamavirus, a new Acanthamoeba polyphaga mimivirus strain, is reported. With 1,191,693 nt in length and 1,023 predicted protein-coding genes, the Mamavirus has the largest genome among the known viruses. The genomes of the Mamavirus and the previously described Mimivirus are highly similar in both the protein-coding genes and the intergenic regions. However, the Mamavirus contains an extra 5′-terminal segment that encompasses primarily disrupted duplicates of genes present elsewhere in the genome. The Mamavirus also has several unique genes including a small regulatory polyA polymerase subunit that is shared with poxviruses. Detailed analysis of the protein sequences of the two Mimiviruses led to a substantial amendment of the functional annotation of the viral genomes.
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spelling pubmed-31634722011-08-29 Viruses with More Than 1,000 Genes: Mamavirus, a New Acanthamoeba polyphaga mimivirus Strain, and Reannotation of Mimivirus Genes Colson, Philippe Yutin, Natalya Shabalina, Svetlana A. Robert, Catherine Fournous, Ghislain La Scola, Bernard Raoult, Didier Koonin, Eugene V. Genome Biol Evol Research Articles The genome sequence of the Mamavirus, a new Acanthamoeba polyphaga mimivirus strain, is reported. With 1,191,693 nt in length and 1,023 predicted protein-coding genes, the Mamavirus has the largest genome among the known viruses. The genomes of the Mamavirus and the previously described Mimivirus are highly similar in both the protein-coding genes and the intergenic regions. However, the Mamavirus contains an extra 5′-terminal segment that encompasses primarily disrupted duplicates of genes present elsewhere in the genome. The Mamavirus also has several unique genes including a small regulatory polyA polymerase subunit that is shared with poxviruses. Detailed analysis of the protein sequences of the two Mimiviruses led to a substantial amendment of the functional annotation of the viral genomes. Oxford University Press 2011-06-24 /pmc/articles/PMC3163472/ /pubmed/21705471 http://dx.doi.org/10.1093/gbe/evr048 Text en Published by Oxford University Press This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Colson, Philippe
Yutin, Natalya
Shabalina, Svetlana A.
Robert, Catherine
Fournous, Ghislain
La Scola, Bernard
Raoult, Didier
Koonin, Eugene V.
Viruses with More Than 1,000 Genes: Mamavirus, a New Acanthamoeba polyphaga mimivirus Strain, and Reannotation of Mimivirus Genes
title Viruses with More Than 1,000 Genes: Mamavirus, a New Acanthamoeba polyphaga mimivirus Strain, and Reannotation of Mimivirus Genes
title_full Viruses with More Than 1,000 Genes: Mamavirus, a New Acanthamoeba polyphaga mimivirus Strain, and Reannotation of Mimivirus Genes
title_fullStr Viruses with More Than 1,000 Genes: Mamavirus, a New Acanthamoeba polyphaga mimivirus Strain, and Reannotation of Mimivirus Genes
title_full_unstemmed Viruses with More Than 1,000 Genes: Mamavirus, a New Acanthamoeba polyphaga mimivirus Strain, and Reannotation of Mimivirus Genes
title_short Viruses with More Than 1,000 Genes: Mamavirus, a New Acanthamoeba polyphaga mimivirus Strain, and Reannotation of Mimivirus Genes
title_sort viruses with more than 1,000 genes: mamavirus, a new acanthamoeba polyphaga mimivirus strain, and reannotation of mimivirus genes
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163472/
https://www.ncbi.nlm.nih.gov/pubmed/21705471
http://dx.doi.org/10.1093/gbe/evr048
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