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Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis

BACKGROUND: ExoU, a Pseudomonas aeruginosa cytotoxin with phospholipase A(2 )activity, was shown to induce vascular hyperpermeability and thrombus formation in a murine model of pneumosepsis. In this study, we investigated the toxin ability to induce alterations in pulmonary fibrinolysis and the con...

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Detalles Bibliográficos
Autores principales:	Machado, Gloria-Beatriz, de Oliveira, Albanita V, Saliba, Alessandra M, de Lima, Carolina D Mallet, Suassuna, José HR, Plotkowski, Maria-Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163543/ https://www.ncbi.nlm.nih.gov/pubmed/21819560 http://dx.doi.org/10.1186/1465-9921-12-104

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