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Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma

BACKGROUND: Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme in the mevalonate pathway leads to suppression of cell proliferation and induction of apoptosis. However, the molecular mechanis...

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Detalles Bibliográficos
Autores principales:	Yanae, Masashi, Tsubaki, Masanobu, Satou, Takao, Itoh, Tatsuki, Imano, Motohiro, Yamazoe, Yuzuru, Nishida, Shozo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163617/ https://www.ncbi.nlm.nih.gov/pubmed/21831290 http://dx.doi.org/10.1186/1756-9966-30-74

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