The Link between the Metabolic Syndrome and Cancer

Since the incidence of the metabolic syndrome is on the rise in the western world, its coherence to cancer is becoming more apparent. In this review we discuss the different potential factors involved in the increase of cancer in the metabolic syndrome including obesity, dyslipidemia and Type 2 Diab...

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Detalles Bibliográficos
Autores principales: Braun, Sandra, Bitton-Worms, Keren, LeRoith, Derek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164150/
https://www.ncbi.nlm.nih.gov/pubmed/21912508
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author Braun, Sandra
Bitton-Worms, Keren
LeRoith, Derek
author_facet Braun, Sandra
Bitton-Worms, Keren
LeRoith, Derek
author_sort Braun, Sandra
collection PubMed
description Since the incidence of the metabolic syndrome is on the rise in the western world, its coherence to cancer is becoming more apparent. In this review we discuss the different potential factors involved in the increase of cancer in the metabolic syndrome including obesity, dyslipidemia and Type 2 Diabetes Mellitus (T2DM) as well as inflammation and hypoxia. We especially focus on the insulin and IGF systems with their intracellular signaling cascades mediated by different receptor subtypes, and suggest that they may play major roles in this process. Understanding the mechanisms involved will be helpful in developing potential therapeutics.
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spelling pubmed-31641502011-09-12 The Link between the Metabolic Syndrome and Cancer Braun, Sandra Bitton-Worms, Keren LeRoith, Derek Int J Biol Sci Review Since the incidence of the metabolic syndrome is on the rise in the western world, its coherence to cancer is becoming more apparent. In this review we discuss the different potential factors involved in the increase of cancer in the metabolic syndrome including obesity, dyslipidemia and Type 2 Diabetes Mellitus (T2DM) as well as inflammation and hypoxia. We especially focus on the insulin and IGF systems with their intracellular signaling cascades mediated by different receptor subtypes, and suggest that they may play major roles in this process. Understanding the mechanisms involved will be helpful in developing potential therapeutics. Ivyspring International Publisher 2011-08-16 /pmc/articles/PMC3164150/ /pubmed/21912508 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
Braun, Sandra
Bitton-Worms, Keren
LeRoith, Derek
The Link between the Metabolic Syndrome and Cancer
title The Link between the Metabolic Syndrome and Cancer
title_full The Link between the Metabolic Syndrome and Cancer
title_fullStr The Link between the Metabolic Syndrome and Cancer
title_full_unstemmed The Link between the Metabolic Syndrome and Cancer
title_short The Link between the Metabolic Syndrome and Cancer
title_sort link between the metabolic syndrome and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164150/
https://www.ncbi.nlm.nih.gov/pubmed/21912508
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