Cargando…

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Chinese hamster ovary (CHO)–derived cell lines are the preferred host cells for the production of therapeutic proteins. Here we present a draft genomic sequence of the CHO-K1 ancestral cell line. The assembly comprises 2.45 Gb of genomic sequence, with 24,383 predicted genes. We associate most of th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Xun, Nagarajan, Harish, Lewis, Nathan E, Pan, Shengkai, Cai, Zhiming, Liu, Xin, Chen, Wenbin, Xie, Min, Wang, Wenliang, Hammond, Stephanie, Andersen, Mikael R, Neff, Norma, Passarelli, Benedetto, Koh, Winston, Fan, H Christina, Wang, Jianbin, Gui, Yaoting, Lee, Kelvin H, Betenbaugh, Michael J, Quake, Stephen R, Famili, Iman, Palsson, Bernhard O, Wang, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164356/ https://www.ncbi.nlm.nih.gov/pubmed/21804562 http://dx.doi.org/10.1038/nbt.1932

Ejemplares similares

Isolation and characterisation of exosomes from Chinese hamster ovary (CHO) cells
por: Skrika-Alexopoulos, Eleftheria, et al.
Publicado: (2023)

A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity
por: Yao, Grace, et al.
Publicado: (2021)

Glycoproteomic Characterization of FUT8 Knock-Out CHO Cells Reveals Roles of FUT8 in the Glycosylation
por: Yang, Ganglong, et al.
Publicado: (2021)

A proteomics approach to decipher a sticky CHO situation
por: Kumar, Swetha, et al.
Publicado: (2022)

SYNCHRONIZATION OF MITOCHONDRIAL DNA SYNTHESIS IN CHINESE HAMSTER CELLS (LINE CHO) DEPRIVED OF ISOLEUCINE
por: Ley, Kenneth D., et al.
Publicado: (1973)

Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines
por: Veith, Nathalie, et al.
Publicado: (2016)

Sequencing the CHO DXB11 genome reveals regional variations in genomic stability and haploidy
por: Kaas, Christian Schrøder, et al.
Publicado: (2015)

A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells
por: Shamie, Isaac, et al.
Publicado: (2021)

Data for engineering lipid metabolism of Chinese hamster ovary (CHO) cells for enhanced recombinant protein production
por: Budge, James D., et al.
Publicado: (2020)

One-Step Enrichment of Intact Glycopeptides From Glycoengineered Chinese Hamster Ovary Cells
por: Yang, Ganglong, et al.
Publicado: (2020)

Enhancing and stabilizing monoclonal antibody production by Chinese hamster ovary (CHO) cells with optimized perfusion culture strategies
por: Liang, Kexue, et al.
Publicado: (2023)

Identification of Mispairing Omic Signatures in Chinese Hamster Ovary (CHO) Cells Producing a Tri-Specific Antibody
por: Sebastião, Maria João, et al.
Publicado: (2023)

Model-based analysis of N-glycosylation in Chinese hamster ovary cells
por: Krambeck, Frederick J., et al.
Publicado: (2017)

CHO microRNA engineering is growing up: Recent successes and future challenges()
por: Jadhav, Vaibhav, et al.
Publicado: (2013)

Identifying deer antler uhrf1 proliferation and s100a10 mineralization genes using comparative RNA-seq
por: Ker, Dai Fei Elmer, et al.
Publicado: (2018)

Tracking Lysosome Migration within Chinese Hamster Ovary (CHO) Cells Following Exposure to Nanosecond Pulsed Electric Fields
por: Thompson, Gary L., et al.
Publicado: (2018)

Single-cell quantification of a broad RNA spectrum reveals unique noncoding patterns associated with cell types and states
por: Isakova, Alina, et al.
Publicado: (2021)

Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages
por: Huhn, Steve, et al.
Publicado: (2022)

A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology
por: Bordbar, Aarash, et al.
Publicado: (2011)

Ca(2+)-induced Ca(2+) Release in Chinese Hamster Ovary (CHO) Cells Co-expressing Dihydropyridine and Ryanodine Receptors
por: Suda, Norio, et al.
Publicado: (1997)

Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype
por: Meleady, Paula, et al.
Publicado: (2011)

The Use of Transcription Terminators to Generate Transgenic Lines of Chinese Hamster Ovary Cells (CHO) with Stable and High Level of Reporter Gene Expression
por: Gasanov, N. B., et al.
Publicado: (2015)

Lysine 268 adjacent to transmembrane helix 5 of hamster P‐glycoprotein is the major photobinding site of iodomycin in CHO B30 cells
por: Demmer, Annette, et al.
Publicado: (2021)

Genomic sequencing and analysis of a Chinese hamster ovary cell line using Illumina sequencing technology
por: Hammond, Stephanie, et al.
Publicado: (2011)

Accelerating Genome Editing in CHO Cells Using CRISPR Cas9 and CRISPy, a Web-Based Target Finding Tool
por: Ronda, Carlotta, et al.
Publicado: (2014)

A reference genome of the Chinese hamster based on a hybrid assembly strategy
por: Rupp, Oliver, et al.
Publicado: (2018)

Metabolic analysis of the asparagine and glutamine dynamics in an industrial Chinese hamster ovary fed‐batch process
por: Kirsch, Brian J., et al.
Publicado: (2022)

Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines
por: Boddapati, Shanta, et al.
Publicado: (2020)

Comparative systeomics to elucidate physiological differences between CHO and SP2/0 cell lines
por: Demirhan, Deniz, et al.
Publicado: (2022)

A Bench-Top Approach for Isolation of Single Antibody Producing Chinese Hamster Ovary (CHO) Cells Using a Microwell-Based Microfluidic Device
por: Fuadiyah, Salma, et al.
Publicado: (2022)

Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding
por: Lu, Rong, et al.
Publicado: (2011)

A Linkage-specific Sialic Acid Labeling Strategy Reveals Different Site-specific Glycosylation Patterns in SARS-CoV-2 Spike Protein Produced in CHO and HEK Cell Substrates
por: Wang, Qiong, et al.
Publicado: (2021)

Influence of cell culture media and feed supplements on cell metabolism and quality of IgG produced in CHO-K1, CHO-S, and CHO-DG44
por: Reinhart, David, et al.
Publicado: (2015)

A novel regulatory element (E77) isolated from CHO‐K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cells
por: Kang, Shin‐Young, et al.
Publicado: (2016)

Retrovectors packaged in CHO cells to generate GLP-1-Fc stable expression CHO cell lines
por: Li, Jing, et al.
Publicado: (2019)

The genome sequence of the colonial chordate, Botryllus schlosseri
por: Voskoboynik, Ayelet, et al.
Publicado: (2013)

Expanded Chinese hamster organ and cell line proteomics profiling reveals tissue-specific functionalities
por: Heffner, Kelley, et al.
Publicado: (2020)

Enhanced Transgene Expression by Optimization of Poly A in Transfected CHO Cells
por: Wang, Xiao-yin, et al.
Publicado: (2022)

Text mining of CHO bioprocess bibliome: Topic modeling and document classification
por: Wang, Qinghua, et al.
Publicado: (2023)

Production and purification of TGFb-1 in CHO-Cells
por: Abdulkerim, Estabraq, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_3dg043tvvm3j3v7d49gq4of833