New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum

Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M–Q (1–5). The structures of compounds 1–5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against...

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Autores principales: Cheng, Shi-Yie, Chen, Pei-Wen, Chen, Hwa-Pyng, Wang, Shang-Kwei, Duh, Chang-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164374/
https://www.ncbi.nlm.nih.gov/pubmed/21892346
http://dx.doi.org/10.3390/md9081307
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author Cheng, Shi-Yie
Chen, Pei-Wen
Chen, Hwa-Pyng
Wang, Shang-Kwei
Duh, Chang-Yih
author_facet Cheng, Shi-Yie
Chen, Pei-Wen
Chen, Hwa-Pyng
Wang, Shang-Kwei
Duh, Chang-Yih
author_sort Cheng, Shi-Yie
collection PubMed
description Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M–Q (1–5). The structures of compounds 1–5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED(50) of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC(50) of 5.2 μg/mL.
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spelling pubmed-31643742011-09-02 New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum Cheng, Shi-Yie Chen, Pei-Wen Chen, Hwa-Pyng Wang, Shang-Kwei Duh, Chang-Yih Mar Drugs Article Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M–Q (1–5). The structures of compounds 1–5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED(50) of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC(50) of 5.2 μg/mL. Molecular Diversity Preservation International 2011-07-27 /pmc/articles/PMC3164374/ /pubmed/21892346 http://dx.doi.org/10.3390/md9081307 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Cheng, Shi-Yie
Chen, Pei-Wen
Chen, Hwa-Pyng
Wang, Shang-Kwei
Duh, Chang-Yih
New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum
title New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum
title_full New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum
title_fullStr New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum
title_full_unstemmed New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum
title_short New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum
title_sort new cembranolides from the dongsha atoll soft coral lobophytum durum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164374/
https://www.ncbi.nlm.nih.gov/pubmed/21892346
http://dx.doi.org/10.3390/md9081307
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