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Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products

The ischemic disorders, in which platelet aggregation and blood coagulation are involved, represent a major cause of disability and death worldwide. The antithrombotic therapy has unsatisfactory performance and may produce side effects. So, there is a need to seek molecules with antithrombotic prope...

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Autores principales: de Andrade Moura, Laura, Ortiz-Ramirez, Fredy, Cavalcanti, Diana Negrao, Ribeiro, Suzi Meneses, Muricy, Guilherme, Teixeira, Valeria Laneuville, Fuly, Andre Lopes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164377/
https://www.ncbi.nlm.nih.gov/pubmed/21892349
http://dx.doi.org/10.3390/md9081346
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author de Andrade Moura, Laura
Ortiz-Ramirez, Fredy
Cavalcanti, Diana Negrao
Ribeiro, Suzi Meneses
Muricy, Guilherme
Teixeira, Valeria Laneuville
Fuly, Andre Lopes
author_facet de Andrade Moura, Laura
Ortiz-Ramirez, Fredy
Cavalcanti, Diana Negrao
Ribeiro, Suzi Meneses
Muricy, Guilherme
Teixeira, Valeria Laneuville
Fuly, Andre Lopes
author_sort de Andrade Moura, Laura
collection PubMed
description The ischemic disorders, in which platelet aggregation and blood coagulation are involved, represent a major cause of disability and death worldwide. The antithrombotic therapy has unsatisfactory performance and may produce side effects. So, there is a need to seek molecules with antithrombotic properties. Marine organisms produce substances with different well defined ecological functions. Moreover, some of these molecules also exhibit pharmacological properties such as antiviral, anticancer, antiophidic and anticoagulant properties. The aim of this study was to evaluate, through in vitro tests, the effect of two extracts of brown algae and ten marine sponges from Brazil on platelet aggregation and blood coagulation. Our results revealed that most of the extracts were capable of inhibiting platelet aggregation and clotting measured by plasma recalcification tests, prothrombin time, activated partial thromboplastin time, and fibrinogenolytic activity. On the other hand, five of ten species of sponges induced platelet aggregation. Thus, the marine organisms studied here may have molecules with antithrombotic properties, presenting biotechnological potential to antithrombotic therapy. Further chemical investigation should be conducted on the active species to discover useful molecules for the development of new drugs to treat clotting disorders.
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spelling pubmed-31643772011-09-02 Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products de Andrade Moura, Laura Ortiz-Ramirez, Fredy Cavalcanti, Diana Negrao Ribeiro, Suzi Meneses Muricy, Guilherme Teixeira, Valeria Laneuville Fuly, Andre Lopes Mar Drugs Article The ischemic disorders, in which platelet aggregation and blood coagulation are involved, represent a major cause of disability and death worldwide. The antithrombotic therapy has unsatisfactory performance and may produce side effects. So, there is a need to seek molecules with antithrombotic properties. Marine organisms produce substances with different well defined ecological functions. Moreover, some of these molecules also exhibit pharmacological properties such as antiviral, anticancer, antiophidic and anticoagulant properties. The aim of this study was to evaluate, through in vitro tests, the effect of two extracts of brown algae and ten marine sponges from Brazil on platelet aggregation and blood coagulation. Our results revealed that most of the extracts were capable of inhibiting platelet aggregation and clotting measured by plasma recalcification tests, prothrombin time, activated partial thromboplastin time, and fibrinogenolytic activity. On the other hand, five of ten species of sponges induced platelet aggregation. Thus, the marine organisms studied here may have molecules with antithrombotic properties, presenting biotechnological potential to antithrombotic therapy. Further chemical investigation should be conducted on the active species to discover useful molecules for the development of new drugs to treat clotting disorders. Molecular Diversity Preservation International 2011-08-10 /pmc/articles/PMC3164377/ /pubmed/21892349 http://dx.doi.org/10.3390/md9081346 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
de Andrade Moura, Laura
Ortiz-Ramirez, Fredy
Cavalcanti, Diana Negrao
Ribeiro, Suzi Meneses
Muricy, Guilherme
Teixeira, Valeria Laneuville
Fuly, Andre Lopes
Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products
title Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products
title_full Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products
title_fullStr Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products
title_full_unstemmed Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products
title_short Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products
title_sort evaluation of marine brown algae and sponges from brazil as anticoagulant and antiplatelet products
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164377/
https://www.ncbi.nlm.nih.gov/pubmed/21892349
http://dx.doi.org/10.3390/md9081346
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