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Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products
The ischemic disorders, in which platelet aggregation and blood coagulation are involved, represent a major cause of disability and death worldwide. The antithrombotic therapy has unsatisfactory performance and may produce side effects. So, there is a need to seek molecules with antithrombotic prope...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164377/ https://www.ncbi.nlm.nih.gov/pubmed/21892349 http://dx.doi.org/10.3390/md9081346 |
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author | de Andrade Moura, Laura Ortiz-Ramirez, Fredy Cavalcanti, Diana Negrao Ribeiro, Suzi Meneses Muricy, Guilherme Teixeira, Valeria Laneuville Fuly, Andre Lopes |
author_facet | de Andrade Moura, Laura Ortiz-Ramirez, Fredy Cavalcanti, Diana Negrao Ribeiro, Suzi Meneses Muricy, Guilherme Teixeira, Valeria Laneuville Fuly, Andre Lopes |
author_sort | de Andrade Moura, Laura |
collection | PubMed |
description | The ischemic disorders, in which platelet aggregation and blood coagulation are involved, represent a major cause of disability and death worldwide. The antithrombotic therapy has unsatisfactory performance and may produce side effects. So, there is a need to seek molecules with antithrombotic properties. Marine organisms produce substances with different well defined ecological functions. Moreover, some of these molecules also exhibit pharmacological properties such as antiviral, anticancer, antiophidic and anticoagulant properties. The aim of this study was to evaluate, through in vitro tests, the effect of two extracts of brown algae and ten marine sponges from Brazil on platelet aggregation and blood coagulation. Our results revealed that most of the extracts were capable of inhibiting platelet aggregation and clotting measured by plasma recalcification tests, prothrombin time, activated partial thromboplastin time, and fibrinogenolytic activity. On the other hand, five of ten species of sponges induced platelet aggregation. Thus, the marine organisms studied here may have molecules with antithrombotic properties, presenting biotechnological potential to antithrombotic therapy. Further chemical investigation should be conducted on the active species to discover useful molecules for the development of new drugs to treat clotting disorders. |
format | Online Article Text |
id | pubmed-3164377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International |
record_format | MEDLINE/PubMed |
spelling | pubmed-31643772011-09-02 Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products de Andrade Moura, Laura Ortiz-Ramirez, Fredy Cavalcanti, Diana Negrao Ribeiro, Suzi Meneses Muricy, Guilherme Teixeira, Valeria Laneuville Fuly, Andre Lopes Mar Drugs Article The ischemic disorders, in which platelet aggregation and blood coagulation are involved, represent a major cause of disability and death worldwide. The antithrombotic therapy has unsatisfactory performance and may produce side effects. So, there is a need to seek molecules with antithrombotic properties. Marine organisms produce substances with different well defined ecological functions. Moreover, some of these molecules also exhibit pharmacological properties such as antiviral, anticancer, antiophidic and anticoagulant properties. The aim of this study was to evaluate, through in vitro tests, the effect of two extracts of brown algae and ten marine sponges from Brazil on platelet aggregation and blood coagulation. Our results revealed that most of the extracts were capable of inhibiting platelet aggregation and clotting measured by plasma recalcification tests, prothrombin time, activated partial thromboplastin time, and fibrinogenolytic activity. On the other hand, five of ten species of sponges induced platelet aggregation. Thus, the marine organisms studied here may have molecules with antithrombotic properties, presenting biotechnological potential to antithrombotic therapy. Further chemical investigation should be conducted on the active species to discover useful molecules for the development of new drugs to treat clotting disorders. Molecular Diversity Preservation International 2011-08-10 /pmc/articles/PMC3164377/ /pubmed/21892349 http://dx.doi.org/10.3390/md9081346 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article de Andrade Moura, Laura Ortiz-Ramirez, Fredy Cavalcanti, Diana Negrao Ribeiro, Suzi Meneses Muricy, Guilherme Teixeira, Valeria Laneuville Fuly, Andre Lopes Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products |
title | Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products |
title_full | Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products |
title_fullStr | Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products |
title_full_unstemmed | Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products |
title_short | Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products |
title_sort | evaluation of marine brown algae and sponges from brazil as anticoagulant and antiplatelet products |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164377/ https://www.ncbi.nlm.nih.gov/pubmed/21892349 http://dx.doi.org/10.3390/md9081346 |
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