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Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium

Chronic ingestion of high concentrations of hexavalent chromium [Cr(VI)] in drinking water induces intestinal tumors in mice. To investigate the mode of action (MOA) underlying these tumors, a 90-day drinking water study was conducted using similar exposure conditions as in a previous cancer bioassa...

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Detalles Bibliográficos
Autores principales:	Thompson, Chad M., Proctor, Deborah M., Haws, Laurie C., Hébert, Charles D., Grimes, Sheila D., Shertzer, Howard G., Kopec, Anna K., Hixon, J.Gregory, Zacharewski, Timothy R., Harris, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Carcinogenicity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164443/ https://www.ncbi.nlm.nih.gov/pubmed/21712504 http://dx.doi.org/10.1093/toxsci/kfr164

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