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Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity

The transition between the closed and open conformations of the Sec61 complex permits nascent protein insertion into the translocation channel. A critical event in this structural transition is the opening of the lateral translocon gate that is formed by four transmembrane (TM) spans (TM2, TM3, TM7,...

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Detalles Bibliográficos
Autores principales:	Trueman, Steven F., Mandon, Elisabet C., Gilmore, Reid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164448/ https://www.ncbi.nlm.nih.gov/pubmed/21737680 http://dx.doi.org/10.1091/mbc.E11-01-0070

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