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Cholesterol Metabolism Is Required for Intracellular Hedgehog Signal Transduction In Vivo

We describe the rudolph mouse, a mutant with striking defects in both central nervous system and skeletal development. Rudolph is an allele of the cholesterol biosynthetic enzyme, hydroxysteroid (17-beta) dehydrogenase 7, which is an intriguing finding given the recent implication of oxysterols in m...

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Detalles Bibliográficos
Autores principales:	Stottmann, Rolf W., Turbe-Doan, Annick, Tran, Pamela, Kratz, Lisa E., Moran, Jennifer L., Kelley, Richard I., Beier, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164675/ https://www.ncbi.nlm.nih.gov/pubmed/21912524 http://dx.doi.org/10.1371/journal.pgen.1002224

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