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DNA Nicks Promote Efficient and Safe Targeted Gene Correction
Targeted gene correction employs a site-specific DNA lesion to promote homologous recombination that eliminates mutation in a disease gene of interest. The double-strand break typically used to initiate correction can also result in genomic instability if deleterious repair occurs rather than gene c...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164693/ https://www.ncbi.nlm.nih.gov/pubmed/21912657 http://dx.doi.org/10.1371/journal.pone.0023981 |