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Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1(G93A) Mouse Model of ALS and Is Harmful in Female Mice

BACKGROUND: Amyotrophic Lateral Sclerosis (ALS) is a devastating neurological disorder characterized by selective degeneration of upper and lower motor neurons. The primary triggers for motor neuron degeneration are unknown but inflammation, oxidative stress and mitochondrial defects have been ident...

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Detalles Bibliográficos
Autores principales:	Kaneb, Hannah M., Sharp, Paul S., Rahmani-Kondori, Nazanin, Wells, Dominic J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164704/ https://www.ncbi.nlm.nih.gov/pubmed/21909419 http://dx.doi.org/10.1371/journal.pone.0024189

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