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Cleavage of von Willebrand Factor by Granzyme M Destroys Its Factor VIII Binding Capacity

Von Willebrand factor (VWF) is a pro-hemostatic multimeric plasma protein that promotes platelet aggregation and stabilizes coagulation factor VIII (FVIII) in plasma. The metalloproteinase ADAMTS13 regulates the platelet aggregation function of VWF via proteolysis. Severe deficiency of ADAMTS13 is a...

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Detalles Bibliográficos
Autores principales:	Hollestelle, Martine J., Lai, Ka Wai, van Deuren, Marcel, Lenting, Peter J., de Groot, Philip G., Sprong, Tom, Bovenschen, Niels
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164717/ https://www.ncbi.nlm.nih.gov/pubmed/21909423 http://dx.doi.org/10.1371/journal.pone.0024216

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