Cargando…

Phospholipase C Isozymes Are Deregulated in Colorectal Cancer – Insights Gained from Gene Set Enrichment Analysis of the Transcriptome

Colorectal cancer (CRC) is one of the most common cancer types in developed countries. To identify molecular networks and biological processes that are deregulated in CRC compared to normal colonic mucosa, we applied Gene Set Enrichment Analysis to two independent transcriptome datasets, including a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Danielsen, Stine A., Cekaite, Lina, Ågesen, Trude H., Sveen, Anita, Nesbakken, Arild, Thiis-Evensen, Espen, Skotheim, Rolf I., Lind, Guro E., Lothe, Ragnhild A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164721/ https://www.ncbi.nlm.nih.gov/pubmed/21909432 http://dx.doi.org/10.1371/journal.pone.0024419

Ejemplares similares

A Tissue-Based Comparative Effectiveness Analysis of Biomarkers for Early Detection of Colorectal Tumors
por: Ahmed, Deeqa, et al.
Publicado: (2012)

Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
por: Berg, Marianne, et al.
Publicado: (2010)

Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival
por: Sveen, Anita, et al.
Publicado: (2011)

Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
por: Lind, Guro E, et al.
Publicado: (2011)

ADAMTS1, CRABP1, and NR3C1 Identified as Epigenetically Deregulated Genes in Colorectal Tumorigenesis
por: Lind, Guro E., et al.
Publicado: (2006)

DNA Sequence Profiles of the Colorectal Cancer Critical Gene Set KRAS-BRAF-PIK3CA-PTEN-TP53 Related to Age at Disease Onset
por: Berg, Marianne, et al.
Publicado: (2010)

Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
por: Jeanmougin, Marine, et al.
Publicado: (2020)

Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains
por: Berg, Kaja C. G., et al.
Publicado: (2019)

MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer
por: Cekaite, Lina, et al.
Publicado: (2015)

Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer
por: Vedeld, Hege Marie, et al.
Publicado: (2018)

Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer
por: Eilertsen, Ina A., et al.
Publicado: (2018)

Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
por: Ahlquist, Terje, et al.
Publicado: (2008)

Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1
por: Sveen, Anita, et al.
Publicado: (2017)

Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer
por: Smeby, Jørgen, et al.
Publicado: (2019)

Hypermethylated MAL gene – a silent marker of early colon tumorigenesis
por: Lind, Guro E, et al.
Publicado: (2008)

SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis
por: Lind, G E, et al.
Publicado: (2011)

Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours – A prognostic test after surgical resection
por: Kolberg, Matthias, et al.
Publicado: (2015)

The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers
por: Marie Vedeld, Hege, et al.
Publicado: (2015)

Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer
por: Smeby, Jørgen, et al.
Publicado: (2019)

CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers
por: Vedeld, Hege Marie, et al.
Publicado: (2017)

The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer
por: Vedeld, Hege Marie, et al.
Publicado: (2014)

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
por: Berg, Kaja C. G., et al.
Publicado: (2017)

Spatial analysis and CD25-expression identify regulatory T cells as predictors of a poor prognosis in colorectal cancer
por: Bergsland, Christian H., et al.
Publicado: (2022)

Transcriptome instability as a molecular pan-cancer characteristic of carcinomas
por: Sveen, Anita, et al.
Publicado: (2014)

The expressed mutational landscape of microsatellite stable colorectal cancers
por: Sveen, Anita, et al.
Publicado: (2021)

Prognostic Significance of β-Catenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series
por: Bruun, Jarle, et al.
Publicado: (2014)

Novel Genomic Aberrations in Testicular Germ Cell Tumors by Array-CGH, and Associated Gene Expression Changes
por: Skotheim, Rolf I., et al.
Publicado: (2006)

The expression and cellular localization of phospholipase D isozymes in the developing mouse testis
por: Kim, Seungjoon, et al.
Publicado: (2007)

Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes
por: Owusu Obeng, Eric, et al.
Publicado: (2020)

Multiregional assessment of CIMP in primary colorectal cancers: Phenotype concordance but marker variability
por: Flatin, Bjørnar T.B., et al.
Publicado: (2020)

Correction: Tumour-infiltrating CD8(+) lymphocytes and colorectal cancer recurrence by tumour and nodal stage
por: Glaire, Mark A., et al.
Publicado: (2019)

Tumour-infiltrating CD8(+) lymphocytes and colorectal cancer recurrence by tumour and nodal stage
por: Glaire, Mark A., et al.
Publicado: (2019)

Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity
por: Smeby, Jørgen, et al.
Publicado: (2020)

Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases
por: Kryeziu, Kushtrim, et al.
Publicado: (2021)

Distribution of phospholipase C isozymes in normal human lung tissue and their immunohistochemical localization.
por: Hwang, S. C., et al.
Publicado: (1996)

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes
por: Siraliev-Perez, Edhriz, et al.
Publicado: (2022)

The Phospholipase A2 Superfamily: Structure, Isozymes, Catalysis, Physiologic and Pathologic Roles
por: Khan, Shibbir Ahmed, et al.
Publicado: (2023)

Emerging Roles of Phospholipase C Beta Isozymes as Potential Biomarkers in Cardiac Disorders
por: Fazio, Antonietta, et al.
Publicado: (2023)

Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis
por: Danielsen, Stine A., et al.
Publicado: (2015)

Genomic and prognostic heterogeneity among RAS/BRAF (V600E)/TP53 co‐mutated resectable colorectal liver metastases
por: Berg, Kaja C. G., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_s433o7odh17gddq4e4r87ksetl