Cargando…

A Computational Approach to Finding Novel Targets for Existing Drugs

Repositioning existing drugs for new therapeutic uses is an efficient approach to drug discovery. We have developed a computational drug repositioning pipeline to perform large-scale molecular docking of small molecule drugs against protein drug targets, in order to map the drug-target interaction s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yvonne Y., An, Jianghong, Jones, Steven J. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164726/ https://www.ncbi.nlm.nih.gov/pubmed/21909252 http://dx.doi.org/10.1371/journal.pcbi.1002139

Ejemplares similares

Complementary Approaches to Existing Target Based Drug Discovery for Identifying Novel Drug Targets
por: Vasaikar, Suhas, et al.
Publicado: (2016)

Roles of existing drug and drug targets for COVID-19 management
por: Ayele, Akeberegn Gorems, et al.
Publicado: (2021)

Predicting existing targets for new drugs base on strategies for missing interactions
por: Shi, Jian-Yu, et al.
Publicado: (2016)

The Existing Methods and Novel Approaches in Mycotoxins’ Detection
por: Janik, Edyta, et al.
Publicado: (2021)

Computational approaches in target identification and drug discovery
por: Katsila, Theodora, et al.
Publicado: (2016)

A computational strategy for finding novel targets and therapeutic compounds for opioid dependence
por: Wu, Xiaojun, et al.
Publicado: (2018)

Fast-Find: A novel computational approach to analyzing combinatorial motifs
por: Hamady, Micah, et al.
Publicado: (2006)

A computational multi-targeting approach for drug repositioning for psoriasis treatment
por: Ibezim, Akachukwu, et al.
Publicado: (2021)

Using Existing Drugs as Leads for Broad Spectrum Anthelmintics Targeting Protein Kinases
por: Taylor, Christina M., et al.
Publicado: (2013)

Corona virus versus existence of human on the earth: A computational and biophysical approach
por: Zehra, Zainy, et al.
Publicado: (2020)

Suprachoroidal Injection: A Novel Approach for Targeted Drug Delivery
por: Wu, Kevin Y., et al.
Publicado: (2023)

Drug repositioning for personalized medicine
por: Li, Yvonne Y, et al.
Publicado: (2012)

Evaluation and integration of existing methods for computational prediction of allergens
por: Wang, Jing, et al.
Publicado: (2013)

Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach
por: Hall, Bethany S., et al.
Publicado: (2019)

RHIC finds hints to why we exist
Publicado: (2010)

Selective Targeting of CTNNB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs
por: Uitdehaag, Joost C. M., et al.
Publicado: (2015)

The Existing Approaches to Sexuality Education Targeting Children: A Review Article
por: GANJI, Jila, et al.
Publicado: (2017)

The Existing Drug Nifuroxazide as an Antischistosomal Agent: In Vitro, In Vivo, and In Silico Studies of Macromolecular Targets
por: Roquini, Vinícius, et al.
Publicado: (2023)

A novel drug response score more accurately predicts renoprotective drug effects than existing renal risk scores
por: Idzerda, Nienke M. A., et al.
Publicado: (2021)

A Survey on the Computational Approaches to Identify Drug Targets in the Postgenomic Era
por: Dai, Yan-Fen, et al.
Publicado: (2015)

Novel Findings of Anti-Filarial Drug Target and Structure-Based Virtual Screening for Drug Discovery
por: Choi, Tae-Woo, et al.
Publicado: (2018)

M2PP: a novel computational model for predicting drug-targeted pathogenic proteins
por: Wang, Shiming, et al.
Publicado: (2022)

A protein interaction map identifies existing drugs targeting SARS-CoV-2
por: Cava, Claudia, et al.
Publicado: (2020)

Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19
por: Norinder, Ulf, et al.
Publicado: (2020)

A Computational Approach Using Bioinformatics to Screening Drug Targets for Leishmania infantum Species
por: Chávez-Fumagalli, Miguel Angel, et al.
Publicado: (2018)

An integrative approach using real-world data to identify alternative therapeutic uses of existing drugs
por: Hosomi, Kouichi, et al.
Publicado: (2018)

Targeting Survivin in Cancer: Novel Drug Development Approaches
por: Groner, Bernd, et al.
Publicado: (2013)

Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment
por: Nagaraj, A B, et al.
Publicado: (2018)

In silico approaches for drug repurposing in oncology: Protocol for a scoping review of existing evidence
por: Cavalcante, Bruno Raphael Ribeiro, et al.
Publicado: (2022)

Novel Computational Approach to Predict Off-Target Interactions for Small Molecules
por: Rao, Mohan S., et al.
Publicado: (2019)

Enriched transcription factor signatures in triple negative breast cancer indicates possible targeted therapies with existing drugs
por: Willis, Scooter, et al.
Publicado: (2015)

Drug Repurposing Approach, Potential Drugs, and Novel Drug Targets for COVID-19 Treatment
por: Kifle, Zemene Demelash, et al.
Publicado: (2021)

A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification
por: Guo, Wei-Feng, et al.
Publicado: (2018)

Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease
por: Tsuji, Shingo, et al.
Publicado: (2021)

Computational discovery and experimental validation of novel drug targets in immuno-oncology
por: Levy, Ofer, et al.
Publicado: (2015)

A novel approach for pineapple leaf fiber processing as an ultimate fiber using existing machines
por: Jalil, Mohammad Abdul, et al.
Publicado: (2021)

A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes
por: Jæger, Karoline Horgmo, et al.
Publicado: (2021)

A Novel Approach of Antiviral Drugs Targeting Viral Genomes
por: Hoang, Phuong Thi, et al.
Publicado: (2022)

Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors
por: Cichonska, Anna, et al.
Publicado: (2017)

Computational Approaches for Drug Discovery
por: Brogi, Simone
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_7mv62tusl5449j88l4f8ab3aif