Fast-spiking interneurons have an initial orientation bias that is lost with vision

We find that following eye opening fast-spiking parvalbumin-positive GABAergic interneurons in mice have well-defined orientation tuning preferences and that subsequent visual experience broadens this tuning. Broad inhibitory tuning is not required for the developmental sharpening of excitatory tuni...

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Autores principales: Kuhlman, Sandra J., Tring, Elaine, Trachtenberg, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164933/
https://www.ncbi.nlm.nih.gov/pubmed/21750548
http://dx.doi.org/10.1038/nn.2890
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author Kuhlman, Sandra J.
Tring, Elaine
Trachtenberg, Joshua T.
author_facet Kuhlman, Sandra J.
Tring, Elaine
Trachtenberg, Joshua T.
author_sort Kuhlman, Sandra J.
collection PubMed
description We find that following eye opening fast-spiking parvalbumin-positive GABAergic interneurons in mice have well-defined orientation tuning preferences and that subsequent visual experience broadens this tuning. Broad inhibitory tuning is not required for the developmental sharpening of excitatory tuning, but does precede binocular matching of orientation tuning. We propose that the experience-dependent broadening of inhibition is a novel candidate for opening the critical period.
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spelling pubmed-31649332012-03-01 Fast-spiking interneurons have an initial orientation bias that is lost with vision Kuhlman, Sandra J. Tring, Elaine Trachtenberg, Joshua T. Nat Neurosci Article We find that following eye opening fast-spiking parvalbumin-positive GABAergic interneurons in mice have well-defined orientation tuning preferences and that subsequent visual experience broadens this tuning. Broad inhibitory tuning is not required for the developmental sharpening of excitatory tuning, but does precede binocular matching of orientation tuning. We propose that the experience-dependent broadening of inhibition is a novel candidate for opening the critical period. 2011-07-12 /pmc/articles/PMC3164933/ /pubmed/21750548 http://dx.doi.org/10.1038/nn.2890 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Kuhlman, Sandra J.
Tring, Elaine
Trachtenberg, Joshua T.
Fast-spiking interneurons have an initial orientation bias that is lost with vision
title Fast-spiking interneurons have an initial orientation bias that is lost with vision
title_full Fast-spiking interneurons have an initial orientation bias that is lost with vision
title_fullStr Fast-spiking interneurons have an initial orientation bias that is lost with vision
title_full_unstemmed Fast-spiking interneurons have an initial orientation bias that is lost with vision
title_short Fast-spiking interneurons have an initial orientation bias that is lost with vision
title_sort fast-spiking interneurons have an initial orientation bias that is lost with vision
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164933/
https://www.ncbi.nlm.nih.gov/pubmed/21750548
http://dx.doi.org/10.1038/nn.2890
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