Alzheimer's risk variants in the clusterin gene are associated with alternative splicing

Genetic variation in CLU encoding clusterin has been associated with Alzheimer's disease (AD) through replicated genome-wide studies, but the underlying mechanisms remain unknown. Following earlier reports that tightly regulated CLU alternative transcripts have different functions, we tested CL...

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Detalles Bibliográficos
Autores principales: Szymanski, M, Wang, R, Bassett, S S, Avramopoulos, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165035/
https://www.ncbi.nlm.nih.gov/pubmed/21892414
http://dx.doi.org/10.1038/tp.2011.17

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