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Can vitamin D(3) supplementation prevent bone loss in persons with MS? A placebo-controlled trial
Multiple sclerosis (MS) is a possible cause of secondary osteoporosis. In this phase II trial we assessed whether a weekly dose of 20,000 IU vitamin D(3) prevents bone loss in ambulatory persons with MS age 18–50 years. ClinicalTrials.gov ID NCT00785473. All patients managed at the University Hospit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165120/ https://www.ncbi.nlm.nih.gov/pubmed/21400196 http://dx.doi.org/10.1007/s00415-011-5980-6 |
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author | Steffensen, Linn H. Jørgensen, Lone Straume, Bjørn Mellgren, Svein Ivar Kampman, Margitta T. |
author_facet | Steffensen, Linn H. Jørgensen, Lone Straume, Bjørn Mellgren, Svein Ivar Kampman, Margitta T. |
author_sort | Steffensen, Linn H. |
collection | PubMed |
description | Multiple sclerosis (MS) is a possible cause of secondary osteoporosis. In this phase II trial we assessed whether a weekly dose of 20,000 IU vitamin D(3) prevents bone loss in ambulatory persons with MS age 18–50 years. ClinicalTrials.gov ID NCT00785473. All patients managed at the University Hospital of North Norway who fulfilled the main inclusion criteria were invited to participate in this double-blinded trial. Participants were randomised to receive 20,000 IU vitamin D(3) or placebo once a week and 500 mg calcium daily for 96 weeks. The primary outcome was the effect of the intervention on percentage change in bone mineral density (BMD) at the hip, the spine, and the ultradistal radius over the study period. Of 71 participants randomised, 68 completed. Mean serum 25-hydroxyvitamin D [25(OH)D] levels in the intervention group increased from 55 nmol/L at baseline to 123 nmol/L at week 96. After 96 weeks, percentage change in BMD did not differ between groups at any site. BMD decreased at the hip, by 1.4% in the placebo group (95% CI −2.3 to −0.4, SD 2.7, p = 0.006) and by 0.7% in the treatment group (−1.6 to 0.2, 2.7, p = 0.118), difference 0.7% (−1.9 to 0.7, p = 0.332). Findings were not altered by adjustment for sex or serum 25(OH)D. Supplementation with 20,000 IU vitamin D(3) a week did not prevent bone loss in this small population. Larger studies are warranted to assess the effect of vitamin D on bone health in persons with MS. |
format | Online Article Text |
id | pubmed-3165120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-31651202011-09-21 Can vitamin D(3) supplementation prevent bone loss in persons with MS? A placebo-controlled trial Steffensen, Linn H. Jørgensen, Lone Straume, Bjørn Mellgren, Svein Ivar Kampman, Margitta T. J Neurol Original Communication Multiple sclerosis (MS) is a possible cause of secondary osteoporosis. In this phase II trial we assessed whether a weekly dose of 20,000 IU vitamin D(3) prevents bone loss in ambulatory persons with MS age 18–50 years. ClinicalTrials.gov ID NCT00785473. All patients managed at the University Hospital of North Norway who fulfilled the main inclusion criteria were invited to participate in this double-blinded trial. Participants were randomised to receive 20,000 IU vitamin D(3) or placebo once a week and 500 mg calcium daily for 96 weeks. The primary outcome was the effect of the intervention on percentage change in bone mineral density (BMD) at the hip, the spine, and the ultradistal radius over the study period. Of 71 participants randomised, 68 completed. Mean serum 25-hydroxyvitamin D [25(OH)D] levels in the intervention group increased from 55 nmol/L at baseline to 123 nmol/L at week 96. After 96 weeks, percentage change in BMD did not differ between groups at any site. BMD decreased at the hip, by 1.4% in the placebo group (95% CI −2.3 to −0.4, SD 2.7, p = 0.006) and by 0.7% in the treatment group (−1.6 to 0.2, 2.7, p = 0.118), difference 0.7% (−1.9 to 0.7, p = 0.332). Findings were not altered by adjustment for sex or serum 25(OH)D. Supplementation with 20,000 IU vitamin D(3) a week did not prevent bone loss in this small population. Larger studies are warranted to assess the effect of vitamin D on bone health in persons with MS. Springer-Verlag 2011-03-13 2011 /pmc/articles/PMC3165120/ /pubmed/21400196 http://dx.doi.org/10.1007/s00415-011-5980-6 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Original Communication Steffensen, Linn H. Jørgensen, Lone Straume, Bjørn Mellgren, Svein Ivar Kampman, Margitta T. Can vitamin D(3) supplementation prevent bone loss in persons with MS? A placebo-controlled trial |
title | Can vitamin D(3) supplementation prevent bone loss in persons with MS? A placebo-controlled trial |
title_full | Can vitamin D(3) supplementation prevent bone loss in persons with MS? A placebo-controlled trial |
title_fullStr | Can vitamin D(3) supplementation prevent bone loss in persons with MS? A placebo-controlled trial |
title_full_unstemmed | Can vitamin D(3) supplementation prevent bone loss in persons with MS? A placebo-controlled trial |
title_short | Can vitamin D(3) supplementation prevent bone loss in persons with MS? A placebo-controlled trial |
title_sort | can vitamin d(3) supplementation prevent bone loss in persons with ms? a placebo-controlled trial |
topic | Original Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165120/ https://www.ncbi.nlm.nih.gov/pubmed/21400196 http://dx.doi.org/10.1007/s00415-011-5980-6 |
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