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Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation
Due primarily to the increasing shortage of allogeneic donor organs, xenotransplantation has become the focus of a growing field of research. Currently, micropigs are the most suitable donor animal for humans. However, no standard method has been developed to evaluate the systemic vascular anatomy o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Veterinary Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165148/ https://www.ncbi.nlm.nih.gov/pubmed/21897092 http://dx.doi.org/10.4142/jvs.2011.12.3.209 |
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author | Ryu, Jung Min Yoon, Woong Park, Jae Hong Yun, Seung Pil Jang, Min Woo Han, Ho Jae |
author_facet | Ryu, Jung Min Yoon, Woong Park, Jae Hong Yun, Seung Pil Jang, Min Woo Han, Ho Jae |
author_sort | Ryu, Jung Min |
collection | PubMed |
description | Due primarily to the increasing shortage of allogeneic donor organs, xenotransplantation has become the focus of a growing field of research. Currently, micropigs are the most suitable donor animal for humans. However, no standard method has been developed to evaluate the systemic vascular anatomy of micropigs and standard reference values to aid in the selection of normal healthy animals as potential organ donors are lacking. Using 64-channel multidetector row computed tomographic angiography (MDCTA), we evaluated morphological features of the major systemic vessels in micropigs and compared our results to published human data. The main vasculature of the animals was similar to that of humans, except for the iliac arterial system. However, diameters of the major systemic vessels were significantly different between micropigs and humans. Specifically, the diameter of the aortic arch, abdominal aorta, external iliac artery, and femoral artery, were measured as 1.50 ± 0.07 cm, 0.85 ± 0.06 cm, 0.52 ± 0.05 cm, and 0.48 ± 0.05 cm, respectively, in the micropigs. This MDCTA data for micropig major systemic vessels can be used as standard reference values for xenotransplantation studies. The use of 64-channel MDCTA enables accurate evaluation of the major systemic vasculature in micropigs. |
format | Online Article Text |
id | pubmed-3165148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Korean Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31651482011-09-12 Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation Ryu, Jung Min Yoon, Woong Park, Jae Hong Yun, Seung Pil Jang, Min Woo Han, Ho Jae J Vet Sci Original Article Due primarily to the increasing shortage of allogeneic donor organs, xenotransplantation has become the focus of a growing field of research. Currently, micropigs are the most suitable donor animal for humans. However, no standard method has been developed to evaluate the systemic vascular anatomy of micropigs and standard reference values to aid in the selection of normal healthy animals as potential organ donors are lacking. Using 64-channel multidetector row computed tomographic angiography (MDCTA), we evaluated morphological features of the major systemic vessels in micropigs and compared our results to published human data. The main vasculature of the animals was similar to that of humans, except for the iliac arterial system. However, diameters of the major systemic vessels were significantly different between micropigs and humans. Specifically, the diameter of the aortic arch, abdominal aorta, external iliac artery, and femoral artery, were measured as 1.50 ± 0.07 cm, 0.85 ± 0.06 cm, 0.52 ± 0.05 cm, and 0.48 ± 0.05 cm, respectively, in the micropigs. This MDCTA data for micropig major systemic vessels can be used as standard reference values for xenotransplantation studies. The use of 64-channel MDCTA enables accurate evaluation of the major systemic vasculature in micropigs. The Korean Society of Veterinary Science 2011-09 2011-08-23 /pmc/articles/PMC3165148/ /pubmed/21897092 http://dx.doi.org/10.4142/jvs.2011.12.3.209 Text en Copyright © 2011 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ryu, Jung Min Yoon, Woong Park, Jae Hong Yun, Seung Pil Jang, Min Woo Han, Ho Jae Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation |
title | Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation |
title_full | Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation |
title_fullStr | Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation |
title_full_unstemmed | Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation |
title_short | Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation |
title_sort | multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165148/ https://www.ncbi.nlm.nih.gov/pubmed/21897092 http://dx.doi.org/10.4142/jvs.2011.12.3.209 |
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