Direct Semi-Synthesis of the Anticancer Lead-Drug Protoapigenone from Apigenin, and Synthesis of Further New Cytotoxic Protoflavone Derivatives

Protoapigenone, a natural flavonoid possessing an unusual p-quinol moiety on its B-ring, is a novel prospective anticancer agent with low toxicity that is currently in development. The first economical, one-step synthesis of protoapigenone from apigenin is described on up to gram scale. 13 new 1′-O-...

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Detalles Bibliográficos
Autores principales: Hunyadi, Attila, Chuang, Da-Wei, Danko, Balazs, Chiang, Michael Y., Lee, Chia-Lin, Wang, Hui-Chun, Wu, Chin-Chung, Chang, Fang-Rong, Wu, Yang-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166065/
https://www.ncbi.nlm.nih.gov/pubmed/21912610
http://dx.doi.org/10.1371/journal.pone.0023922

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