Readthrough of Premature Termination Codons in the Adenomatous Polyposis Coli Gene Restores Its Biological Activity in Human Cancer Cells

The APC tumor suppressor gene is frequently mutated in human colorectal cancer, with nonsense mutations accounting for 30% of all mutations in this gene. Reintroduction of the WT APC gene into cancer cells generally reduces tumorigenicity or induces apoptosis. In this study, we explored the possibil...

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Detalles Bibliográficos
Autores principales: Floquet, Célia, Rousset, Jean-Pierre, Bidou, Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166079/
https://www.ncbi.nlm.nih.gov/pubmed/21909382
http://dx.doi.org/10.1371/journal.pone.0024125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166079/
https://www.ncbi.nlm.nih.gov/pubmed/21909382
http://dx.doi.org/10.1371/journal.pone.0024125

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