LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster

In animals, male fertility requires the successful development of motile sperm. During Drosophila melanogaster spermatogenesis, 64 interconnected spermatids descended from a single germline stem cell are resolved into motile sperm in a process termed individualization. Here we identify a putative do...

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Detalles Bibliográficos
Autores principales: Sanders, Charcacia, Smith, Dean P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166160/
https://www.ncbi.nlm.nih.gov/pubmed/21912621
http://dx.doi.org/10.1371/journal.pone.0024151
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author Sanders, Charcacia
Smith, Dean P.
author_facet Sanders, Charcacia
Smith, Dean P.
author_sort Sanders, Charcacia
collection PubMed
description In animals, male fertility requires the successful development of motile sperm. During Drosophila melanogaster spermatogenesis, 64 interconnected spermatids descended from a single germline stem cell are resolved into motile sperm in a process termed individualization. Here we identify a putative double-stranded RNA binding protein LUMP that is required for male fertility. lump(1) mutants are male-sterile and lack motile sperm due to defects in sperm individualization. We show that one dsRNA binding domains (dsRBD) is essential for LUMP function in male fertility. These findings reveal LUMP is a novel factor required for late stages of male germline differentiation.
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spelling pubmed-31661602011-09-12 LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster Sanders, Charcacia Smith, Dean P. PLoS One Research Article In animals, male fertility requires the successful development of motile sperm. During Drosophila melanogaster spermatogenesis, 64 interconnected spermatids descended from a single germline stem cell are resolved into motile sperm in a process termed individualization. Here we identify a putative double-stranded RNA binding protein LUMP that is required for male fertility. lump(1) mutants are male-sterile and lack motile sperm due to defects in sperm individualization. We show that one dsRNA binding domains (dsRBD) is essential for LUMP function in male fertility. These findings reveal LUMP is a novel factor required for late stages of male germline differentiation. Public Library of Science 2011-08-30 /pmc/articles/PMC3166160/ /pubmed/21912621 http://dx.doi.org/10.1371/journal.pone.0024151 Text en Sanders, Smith. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sanders, Charcacia
Smith, Dean P.
LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster
title LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster
title_full LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster
title_fullStr LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster
title_full_unstemmed LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster
title_short LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster
title_sort lump is a putative double-stranded rna binding protein required for male fertility in drosophila melanogaster
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166160/
https://www.ncbi.nlm.nih.gov/pubmed/21912621
http://dx.doi.org/10.1371/journal.pone.0024151
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