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von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes
Considering the role of von Willebrand factor (vWf) in hemostasis, and the role of oxidative stress in the development of endothelial dysfunction and atherosclerotic disease, the aim of our study was to investigate the relationship between vWf, parameters of oxidative stress and different types of a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166185/ https://www.ncbi.nlm.nih.gov/pubmed/21904649 http://dx.doi.org/10.1155/2011/918312 |
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author | Koprivica, Zoran Djordjevic, Dusica Vuletic, Milena Zivkovic, Vladimir Barudzic, Nevena Andjelkovic, Nebojsa Djuric, Dragan Iric-Cupic, Violeta Krkeljic, Jelena Jakovljevic, Vladimir |
author_facet | Koprivica, Zoran Djordjevic, Dusica Vuletic, Milena Zivkovic, Vladimir Barudzic, Nevena Andjelkovic, Nebojsa Djuric, Dragan Iric-Cupic, Violeta Krkeljic, Jelena Jakovljevic, Vladimir |
author_sort | Koprivica, Zoran |
collection | PubMed |
description | Considering the role of von Willebrand factor (vWf) in hemostasis, and the role of oxidative stress in the development of endothelial dysfunction and atherosclerotic disease, the aim of our study was to investigate the relationship between vWf, parameters of oxidative stress and different types of acute coronary syndromes (ACS). Levels of vWf activity (vWfAct), vWf antigen (vWfAg), nitric oxide (estimated through nitrites–NO(2) (−)), superoxide anion radical (O(2) (−)), hydrogen peroxide (H(2)O(2)), index of lipid peroxidation (estimated through thiobarbituric acid reactive substances–TBARS), superoxide dismutase (SOD) and catalase (CAT) activity of 115 patients were compared with those of 40 healthy controls. ACS patients had significantly higher vWfAct and vWfAg levels, as well as TBARS levels, while their levels of NO(2) (−), H(2)O(2), SOD and CAT activities were lower than controls'. vWfAg showed high specificity and sensitivity as a test to reveal healthy or diseased subjects. Multivariant logistic regression marked only vWfAg and TBARS as parameters that were under independent effect of ACS type. The results of our study support the implementation of vWf in clinical rutine and into therapeutic targets, and suggest that ACS patients are in need of antioxidant supplementation to improve their impaired antioxidant defence. |
format | Online Article Text |
id | pubmed-3166185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31661852011-09-08 von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes Koprivica, Zoran Djordjevic, Dusica Vuletic, Milena Zivkovic, Vladimir Barudzic, Nevena Andjelkovic, Nebojsa Djuric, Dragan Iric-Cupic, Violeta Krkeljic, Jelena Jakovljevic, Vladimir Oxid Med Cell Longev Research Article Considering the role of von Willebrand factor (vWf) in hemostasis, and the role of oxidative stress in the development of endothelial dysfunction and atherosclerotic disease, the aim of our study was to investigate the relationship between vWf, parameters of oxidative stress and different types of acute coronary syndromes (ACS). Levels of vWf activity (vWfAct), vWf antigen (vWfAg), nitric oxide (estimated through nitrites–NO(2) (−)), superoxide anion radical (O(2) (−)), hydrogen peroxide (H(2)O(2)), index of lipid peroxidation (estimated through thiobarbituric acid reactive substances–TBARS), superoxide dismutase (SOD) and catalase (CAT) activity of 115 patients were compared with those of 40 healthy controls. ACS patients had significantly higher vWfAct and vWfAg levels, as well as TBARS levels, while their levels of NO(2) (−), H(2)O(2), SOD and CAT activities were lower than controls'. vWfAg showed high specificity and sensitivity as a test to reveal healthy or diseased subjects. Multivariant logistic regression marked only vWfAg and TBARS as parameters that were under independent effect of ACS type. The results of our study support the implementation of vWf in clinical rutine and into therapeutic targets, and suggest that ACS patients are in need of antioxidant supplementation to improve their impaired antioxidant defence. Hindawi Publishing Corporation 2011 2011-08-08 /pmc/articles/PMC3166185/ /pubmed/21904649 http://dx.doi.org/10.1155/2011/918312 Text en Copyright © 2011 Zoran Koprivica et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Koprivica, Zoran Djordjevic, Dusica Vuletic, Milena Zivkovic, Vladimir Barudzic, Nevena Andjelkovic, Nebojsa Djuric, Dragan Iric-Cupic, Violeta Krkeljic, Jelena Jakovljevic, Vladimir von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes |
title | von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes |
title_full | von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes |
title_fullStr | von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes |
title_full_unstemmed | von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes |
title_short | von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes |
title_sort | von willebrand factor and oxidative stress parameters in acute coronary syndromes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166185/ https://www.ncbi.nlm.nih.gov/pubmed/21904649 http://dx.doi.org/10.1155/2011/918312 |
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