The C-terminal region of Bfl-1 sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing NF-κB activity and down-regulating Bfl-1

Gemcitabine is used to treat several cancers including lung cancer. However, tumor cells often escape gemcitabine-induced cell death via various mechanisms, which include modulating bcl-2 family members and NF-κB activation. We previously reported that the C-terminal region of Bfl-1 fused with GFP (...

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Detalles Bibliográficos
Autores principales: Kim, Min-Kyoung, Jeon, Yoon-Kyung, Woo, Jong-Kyu, Choi, Yun, Choi, Dae-Han, Kim, Yeul-Hong, Kim, Chul-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166274/
https://www.ncbi.nlm.nih.gov/pubmed/21843371
http://dx.doi.org/10.1186/1476-4598-10-98

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